COMMON BRAND NAME(S): Tricor, Triglide
GENERIC NAME(S): FENOFIBRATE
Description: Fenofibrate lowers cholesterol and triglycerides by activating lipoprotein lipase, which increases the destruction of VLDL and increase in HDL levels, the good cholesterol.
Absorption: Readily absorbed from the GI tract. Increased bioavailabilty w/ food, particularly w/ a high fat meal but is not affected if given as choline salt. Bioavailability: Approx 81% (active metabolite). Time to peak plasma concentration: 2-8 hr.
Distribution: Widely distributed to most tissues. Plasma protein binding: Approx 99% (albumin).
Metabolism: Rapidly hydrolysed to fenofibric acid (active metabolite).
Excretion: Mainly via urine (60% as metabolite); faeces (25%). Elimination half-life: Approx 20 hr.