Follicular dendritic cell sarcoma (FDC) is a form of sarcoma that is extremely rare. Most of its signs, including inflamed lymph nodes that aren’t painful, are similar to lymphoma. This is a type of cancer that influences the blood.

FDC is classified as a soft tissue sarcoma by doctors. The lymph nodes produce specialized cells that give rise to FDC sarcoma. Moreover, the lymphatic system, which aids in infection prevention, incorporates lymph nodes.

Nodal malignancies are (FDC) sarcomas that form in the lymph nodes. However, roughly 30 of every 100 people experience problems elsewhere in the body, including:

  • Skin
  • Spleen
  • Digestive system
  • Liver
  • Neck and head area
  • the area between the lungs and the center of the chest

Since they grow outside of the normal lymph nodes, these FDC are called extranodal tumors.


FDC sarcoma has different signs, depending on where it arises in the body. Painless enlargement of a lymph node, commonly in the neck, is the most prevalent sign. Swelling, on the other hand, can happen anywhere throughout the lymphatic system.

Some signs and symptoms could include:

  • Sore throat
  • Cough
  • Tiredness
  • Weight loss
  • Abdominal pain
  • Fever
  • Night sweats


Your doctor may ask about your health history in order to diagnose FDC. You can also be subjected to a number of tests. These include the following:

  • Blood tests
  • PET scan
  • CT scan
  • Chest X-ray

The only way to be certain about a diagnosis is to collect a sample of cells from the tumor and examine them under a microscope. FDC can be hard to distinguish from other forms of cancer.

Another test that can help diagnose your condition is immunohistochemical staining. Protein markers are found on cells of FDC. CD23, CD21, and CD35 are three particular proteins. These can be tested by professionals to verify the diagnosis.


Because FDC sarcoma is so uncommon, treatment standards aren’t as clear as they are for most other malignancies.

The following factors influence your treatment:

  • what size the sarcoma is and if it has disseminated to other regions of the body;
  • your overall fitness and health; and
  • how sarcoma cells vary from healthy cells and how quickly they grow.

Following an operation to remove cancer, you may receive radiotherapy or chemotherapy.

It’s extremely difficult to deal with a rare cancer diagnosis. So, learning more about your disease and how to treat it can be beneficial.

Related Articles


Overview and FactsTypes and SymptomsDiagnosis & MedicationsOverview and Facts Familial alobar holoprosencephaly, also known as cyclopia, is an uncommon and [...]


Overview and FactsTypes and SymptomsDiagnosis & MedicationsOverview and Facts Nystagmus benign paroxysmal positional is the most common cause of vertigo [...]


Overview and FactsTypes and SymptomsDiagnosis & MedicationsOverview and Facts Noninfectious uveitis is when one or both of your eyes experience [...]