Ethinylestradiol is a synthetic estrogen while gestodene is a progestogen. They work together to prevent ovulation by inhibiting gonadotropin release. Other factors that contribute to its contraceptive efficacy include changes in cervical mucus (which makes sperm entry into the uterus more difficult) and the endometrium (which reduces the chance of implantation).

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Ethinylestradiol + Gestodene is used in the following conditions:

  • Oral contraception

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Ethinylestradiol + Gestodene in people with the following conditions:

  • Pulmonary embolism
  • Deep vein thrombosis
  • Activated Protein C (APC) resistance
  • Antithrombin-III deficiency
  • Protein C or S deficiency
  • Conditions requiring prolonged immobilisation 
  • Stroke
  • Myocardial infarction
  • Angina pectoris
  • Transient ischemic attack
  • Hyperhomocysteinemia
  • Anti-phospholipid antibodies
  • Aura
  • Severe hypertension
  • Diabetes mellitus with vascular symptoms
  • Current or history of pancreatitis associated with severe hypertriglyceridemia
  • Undiagnosed abnormal genital bleeding
  • Breast or other estrogen-dependent neoplasms
  • Current or history of hepatic adenoma or carcinoma
  • Severe hepatic impairment
  • Pregnancy
  • Concomitant use with the medicinal products containing ombitasvir/paritaprevir/ritonavir and dasabuvir (with or without ribavirin) 

Ethinylestradiol + Gestodene may have the following side effects:

  • Chloasma
  • Breakthrough bleeding
  • Spotting
  • Cholestasis
  • Lipid changes
  • Glucose intolerance
  • Gallbladder disease
  • Fluid retention
  • Headache (migraine)
  • Optic neuritis
  • Retinal vascular thrombosis
  • Intolerance to contact lenses
  • Abdominal pain
  • Nausea
  • Vomiting
  • Increased or decreased weight
  • Dizziness
  • Nervousness
  • Altered or depressed mood
  • Amenorrhea
  • Dysmenorrhea
  • Breast tenderness, pain or enlargement
  • Changes in libido
  • Menstrual flow and cervical secretion or ectropion

Potentially Fatal:

  • Deep vein thrombosis
  • Pulmonary embolism
  • Myocardial infarction
  • Stroke
  • Transient ischemic attack
  • Hypertension
  • Increased risk of breast, cervical, endometrial or ovarian cancer 
  • Hepatic adenoma or carcinoma

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Crohn’s disease
  • Ulcerative colitis
  • Gallbladder disease
  • Systemic lupus erythematosus (SLE)
  • Epilepsy
  • History of depression
  • Hereditary angioedema
  • Hypertension
  • Dyslipidemia
  • Asthma
  • Obese patients
  • Smokers (women more than 35 years old)
  • Renal and mild to moderate hepatic impairment
  • Lactation

Prior in taking this medicine, tell your physician or pharmacist if you have allergies or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.


Ethinylestradiol + Gestodene may interact with the following medicines:


  • Nevirapine
  • Barbiturates
  • Phenytoin
  • Ampicillin
  • Rifampicin
  • Griseofulvin
  • Itraconazole
  • Erythromycin
  • Ascorbic acid
  • Paracetamol
  • Atorvastatin
  • Etoricoxib
  • Ciclosporin
  • Theophylline
  • Tizanidine
  • Lamotrigine

Potentially Fatal: 

  • Ombitasvir
  • Paritaprevir
  • Ritonavir
  • Dasabuvir (with or without ribavirin)

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.


  • Nausea
  • Vomiting
  • Withdrawal bleeding

If an overdose is suspected, call your health care provider immediately.

Available brands:

  • Gynera
  • Meliane
  • Sophia
  • Femodene
  • Minulet

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