HUMAN PAPILLOMAVIRUS 9-VALENT VACCINE

Estradiol + Dydrogesterone

Estradiol is a synthetic sex hormone similar to endogenous estrogen. During menopause, estradiol replenishes low estrogen and relieve its symptoms. Estradiol also inhibits bone loss following menopause or ovariectomy.

Dydrogesterone is a synthetic sex hormone similar to progestogen. It alleviates the estradiol-induced risk of endometrial hyperplasia in non-hysterectomised women.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Estradiol + Dydrogesterone  is used in the following conditions:

  • Menopausal hormone replacement therapy
  • Prophylaxis of postmenopausal osteoporosis

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Estradiol + Dydrogesterone in people with the following conditions:

  • History of or suspected breast cancer
  • Endometrial cancer
  • Progestogen-dependent neoplasms
  • Venous and arterial thromboembolism
  • Cerebrovascular accident (Stroke)
  • Thrombophilic disorders
  • Untreated endometrial hyperplasia
  • Undiagnosed genital bleeding
  • Porphyria
  • Hepatic impairment
  • Pregnancy and lactation

Estradiol + Dydrogesterone may have the following side effects:

  • May increase risk of breast, endometrial and ovarian cancers
  • May increase risk of dementia
  • Venous thromboembolism
  • Pulmonary emboli
  • Myocardial Infarction
  • Stroke
  • Hypertension
  • Gall bladder disease
  • Endometrial hyperplasia
  • Migraine
  • Jaundice
  • Abnormal liver function test
  • Increased thyroid binding globulin levels
  • Visual abnormalities
  • Abdominal pain
  • Nausea
  • Vomiting
  • Flatulence
  • Fatigue
  • Asthenia
  • Malaise
  • Increased or decreased weight
  • Peripheral edema
  • Headache
  • Migraine
  • Dizziness
  • Depression
  • Nervousness
  • Breast pain or tenderness
  • Menstrual disorders
  • Pelvic pain
  • Vaginal discharge
  • Vaginal candidiasis
  • Rash
  • Pruritus
  • Urticaria

 

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Patient with history of endometrial hyperplasia
  • Risk factors for estrogen-dependent tumors
  • Venous and arterial thromboembolism
  • Cardiac impairment
  • Hypertension
  • Diabetes mellitus
  • Asthma
  • Cholelithiasis
  • Uterine fibroids
  • Endometriosis
  • Migraine
  • Epilepsy
  • Systemic lupus erythematosus
  • Otosclerosis
  • Hypertriglyceridemia
  • Patient who underwent hysterectomy
  • Surgery
  • Smokers
  • Renal impairment
  • Elderly

Prior in taking this medicine, tell your physician or pharmacist if you have allergies  or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

 

Interactions

Estradiol + Dydrogesterone may interact with the following medicines:

CYP enzyme inducers

  • Phenobarbital
  • Rifampicin
  • Nevirapine
  • Theophylline
  • Tacrolimus
  • Fentanyl

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you think you have used Estradiol + Dydrogesterone more than the usual dosage, please seek medical help immediately.

Symptoms of overdose may include the following:

  • Nausea
  • Vomiting
  • Abdominal pain
  • Dizziness
  • Drowsiness
  • Fatigue
  • Breast tenderness
  • Withdrawal bleeding

 

Available Brands:

  • Femoston
  • Duphaston

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