HUMAN PAPILLOMAVIRUS 9-VALENT VACCINE

ERGOTAMINE + CAFFEINE

Ergotamine is a partial serotonin agonist with vasoconstrictor effects. It is an ergot alkaloid and has an important oxytocic role on the uterus. It encourages the vasoconstriction of peripheral smooth muscles and cranial blood vessels, and slows down the central vasomotor activity.

Caffeine blocks the phosphodiesterase enzyme that causes an elevation of intracellular cyclic 3,5 adenosine monophosphate levels. It inhibits the peripheral pronociceptive property of adenosine and stimulates the central noradrenergic pathway which comprises an endogenous pain suppression system that causes its analgesic action. It raises the ergotamine enteral absorption and its vasoconstrictive activity. It also impedes the central adenosine receptors hence restoring the CNS and resp center, generating wakefulness, enhanced mental property, raises rate and respiration depth.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Ergotamine + Caffeine is used in the following conditions:

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.  

Do not use Ergotamine + Caffeine in people with the following conditions:

  • Peripheral vascular disease
  • Obliterative vascular disease
  • Heart disease
  • Hypertension
  • Septic conditions
  • Severe renal and hepatic impairment
  • Pregnancy
  • Lactation

Ergotamine + Caffeine may have the following side effects:

  • Vasospasm
  • Myocardial ischaemia
  • Ergotism
  • Pleural retroperitoneal
  • Pulmonary fibrosis
  • Drug-induced headaches
  • Dependence
  • Headache
  • Transient loss of vision
  • Rarely, infarction
  • Dizziness
  • Numbness
  • Paraesthesia
  • Drowsiness
  • Precordial pain
  • Vertigo
  • Peripheral vasoconstriction
  • Cold extremities
  • ECG changes
  • Edema
  • Transient bradycardia
  • Tachycardia
  • Hypertension
  • Anal fissure
  • Nausea
  • Rectal ulcers
  • Vomiting
  • Abdominal pain
  • Diarrhea
  • Cyanosis
  • Myalgia
  • Weakness
  • Gangrene
  • Pruritus
  • Rash
  • Urticaria

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

  • Patients with risk or predisposed vascular effects

Prior in taking this medicine, tell your physician or pharmacist if you have allergies  or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Ergotamine + Caffeine may interact with the following medicines:

    • Ergotamine: Beta-blockers
    • Caffeine: Mexiletine, fluvoxamine, oral contraceptives and sympathomimetics
  • Potentially fatal: Potent CYP3A4 inhibitors, sympathomimetics, ergot alkaloids, nicotine

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If an overdose is suspected, call your health care provider immediately.

  • Nausea
  • Vomiting
  • Drowsiness
  • Confusion
  • Shock
  • Coma
  • Symptoms and complications of ergotism

Available brands:

  • Cafergot
  • Ercaf
  • Wigraine

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