Edrophonium chloride is a drug belonging to a class of medicines known as synthetic quaternary ammonium cholinergic agents. It inhibits acetylcholine hydrolysis and leads to the accumulation of acetylcholine. This further increases cholinergic response such as increased muscle tone, bronchial constriction, ureteral constriction, decreased hear rate, miosis and increased sweat and salivary secretions.
Edrophonium chloride is used in the following:
Do not use in those with mechanical obstruction of the gastrointestinal or genitourinary tract.
Edrophonium chloride may give rise to side effects such as the following:
Precautions
Take extra caution in patients with the following conditions:
Interactions
Edrophonium chloride can interact with the following medicines:
Edrophonium chloride overdose can start a cholinergic crisis with symptoms such as nausea, vomiting, diarrhoea, excessive sweating, increased bronchial and salivary secretions, bradycardia or tachycardia, cardiospasm, hypotension, blurred vision, weakness, incoordination, muscle cramps, fasciculation, paralysis, bronchospasm, airway obstruction, respiratory paralysis, pulmonary edema, cardiac arrest.
Seek medical help immediately.
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