EDOXABAN

Edoxaban is a specific, reversible and direct inhibitor of factor Xa. It limits factor Xa, prothrombinase action and thrombin-incited platelet aggregation in the coagulation process, further diminishing thrombin production, prolonging coagulation time and diminishing the risk of thrombus creation.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Uses

Edoxaban is used in the following conditions:

Prophylaxis of stroke and systemic embolism in non-valvular atrial fibrillation
Deep vein thrombosis
Pulmonary embolism

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Warnings

Do not use Edoxaban in people with the following conditions:

Active pathological bleeding
Liverdisease associated with coagulopathy and clinically relevant bleeding risk
Conditions with significant risk of bleeding
Current or recent gastrointestinal ulceration
Malignant neoplasms
Recent brainsurgery
Spinalsurgery
Ophthalmic injury and/or surgery
Recent intracranial hemorrhage
Known or suspected esophageal varices
Arteriovenous malformations
Vascular aneurysms
Major intraspinal or intracerebral vascular abnormalities
Uncontrolled severe hypertension
Concomitant use with parenteral anticoagulants except when given to maintain an open central venous or arterial catheter
Oral anticoagulants except when switching oral anticoagulant therapy
Pregnancy

Side Effects

Edoxaban may have the following side effects:

Thromboembolic events
Spinal or epidural hematoma resulting to long term or permanent paralysis
Anemia
Nausea
Abdominal pain
Lower and upper gastrointestinal hemorrhage
Oral/pharyngeal hemorrhage
Puncture site hemorrhage.
Increased serum gammaglutamyltransferase
Increased serum bilirubin
Headache
Dizziness
Macroscopic hematuria/urethral hemorrhage
Vaginal hemorrhage
Cutaneous and soft tissue hemorrhage rash
Pruritus
Epistaxis
Bleeding

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist

Precautions

Take extra caution in patients with the following medical conditions:

Patient with increased risk of bleeding
History of traumatic or repeated spinal/epidural puncture
Spinal deformity or surgery
Renal and hepatic impairment
Elderly
Lactation
Not recommended for the treatment ofpatients with prosthetic heart valve or significant rheumatic heart disease
Concomitant use with neuraxial anaesthesia

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Edoxaban may interact with the following medicines:

Neuraxial anesthesia
Rifampicin
Carbamazepine
Ciclosporin
Erythromycin
Azithromycin
Itraconazole
Ketoconazole
Amiodarone
Verapamil
Quinidine
Aspirin
Clopidogrel
SSRIs
NSAIDs

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Overdose & Brands

Symptoms of overdose include:

Hemorrhage
Severe epistaxis

Seek medical help immediately.

Available Brand:

Lixiana