Ectodermosis erosiva pluriorificialis is a significant skin and mucous membrane condition. It’s usually the result of a medication reaction that begins with flu-like signs and escalates to a painful rash accompanying blisters. In a few days, the affected skin’s top layer peels and starts to heal.

It is a medical emergency that often needs admission to the hospital. The goal of treatment is to eliminate the source, care for wounds, reduce pain, and minimize complications as the skin regrows. Recovery can take weeks or months.

Toxic epidermal necrolysis is a more severe manifestation of the illness. It impacts more than 30% of the skin’s surface and damages the mucous membranes significantly. If a medication triggers your problem, you’d have to stay away from it and others like it for the rest of your life.


You may show early indicators of ectodermosis erosiva pluriorificialis one to three days before a rash appears, such as:

Other signs and symptoms as the illness worsens are:

  • Widespread, unexplained skin pain
  • Purple or red rash
  • Blisters on the skin, eyes, mouth, genitals, nose
  • Shedding of the skin

Ectodermosis erosiva pluriorificialis necessitates medical attention right away. If you experience any problems, seek medical help immediately. However, note that drug-induced reactions can happen while you’re taking medicine or up to two weeks after you stop using it.


The following tests and methods are used to diagnose ectodermosis erosiva pluriorificialis:

  • Physical exam and assessment of medical history
  • Skin biopsy
  • Culture
  • Blood tests
  • Imaging


Ectodermosis erosiva pluriorificialis requires hospitalization, either in a burn or intensive care unit.

  • Getting Rid of Non-Essential Drugs. Stopping any drugs that may be causing Stevens-Johnson syndrome is the first and most crucial step in treating it. If you are taking many drugs, it may be tough to predict which one is causing the issue. As a result, your physician may urge you to stop taking any medications that aren’t absolutely necessary.
  • Supportive Care. Wound treatment, fluid replacement and nourishment, and eye care are all kinds of supportive care you’ll likely receive while in the hospital.
  • Medications. Pain relievers, antibiotics, oral or injectable drugs, and anti-inflammatory medications are among the medications used to treat the syndrome.

Related Articles


Overview and FactsTypes and SymptomsDiagnosis & MedicationsOverview and Facts Nystagmus benign paroxysmal positional is the most common cause of vertigo [...]


Overview and FactsTypes and SymptomsDiagnosis & MedicationsOverview and Facts Noninfectious uveitis is when one or both of your eyes experience [...]


Overview and FactsTypes and SymptomsDiagnosis & MedicationsOverview and Facts Necrotizing fasciitis of the perineum is an uncommon, potentially fatal bacterial [...]