Dowling-Meara syndrome is a form of epidermolysis bullosa simplex determined by the formation of clustered or arcuate generalized vesicles and tiny blisters. This syndrome is the most severe form of the illness, where blisters may develop in clusters and anywhere in the body. Nevertheless, this condition often improves with age, but those who develop this syndrome may suffer from hyperkeratosis on the soles and palms, as well as abnormal growth of nails.


When it comes to Dowling-Meara syndrome, some patients may show more signs, ranging from moderate to severe. This disease might cause these signs:

  • Skin or mucous membrane redness
  • Having trouble eating
  • Hypermetropia
  • Scarring
  • Unusual blistering
  • Abnormal morphology of the epiglottis
  • Abnormal larynx
  • Alopecia
  • Hair loss
  • Weakness in weight
  • Scars that have become atrophic
  • Bronchomalacia
  • Nystagmu, which is a condition that is present at birth
  • Opacity of the cornea

Some indications may affect many bodily systems, which includes the respiratory, circulatory, skeletal, musclar, neurological, digestive tract, adrenal gland, immunological system, epidermis system, excretory system, and reproductive functions.


Speaking with a doctor frequently throughout the diagnosis may be beneficial and required. A skin biopsy testing is used to identify Dowling-Meara syndrome. A doctor takes a tiny skin sample and examines it behind a microscope in this procedure. Aside from that, genetic screening may validate the kind of EB—whether it is Dowling-Meara syndrome or not—by detecting the faulty gene.


Dowling-Meara syndrome has no known cure. Neverhteless, treatment focuses on preventing blisters, treating for blisters and skin to avoid problems, addressing nutritional issues that may arise from blisters in the throat or esophagus, and controlling discomfort.

Doctors advise that to minimize damage and tension that might cause blistering or tearing of the skin, you should:

  • Wearing loose-fitting, comfortable garments
  • Keeping rooms at a pleasant and uniform temperature to avoid feeling overly hot
  • Avoiding the sun or using sunscreen
  • Using non-adhesive (does not attach to the skin) bandages and tape and rolled gauze to prevent irritation.

In addition, your doctor may suggest the following treatments to treat blisters:

  • Using ointments to treat wounds regularly
  • Using medicinal bandages to aid in the healing and prevention of blisters
  • Taking medications that can help deal with the pain

Your doctor may suggest the following treatments to cure infections:

  • Antibiotics may be taken orally or used topically.
  • For non-healing sores, a specific wound dressing is used.

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