Doravirine is a pyridinone non-nucleoside reverse transcriptase inhibitor (NNRTI) that reduces HIV-1 replication by competing with reverse transcriptase’s viral polymerase activity (RT). It interacts to a hydrophobic pocket in the p66 subunit of the RT enzyme’s p66/p51 heterodimer, producing conformational changes in the active site residues. This results in an inactive form, which prevents the chemical action of a polymerisation process from taking place.
Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.
The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.
If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.
Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.
If you have any inquiries with regards to information, ask your physician or pharmacist.