DOLASETRON

COMMON BRAND NAME(S): Anzemet

GENERIC NAME(S): DOLASETRON MESYLATE

 

Description: Dolasetron blocks serotonin both peripherally (main site of action) and centrally at the chemoreceptor trigger zone.

This is used to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) by blocking serotonin.

How to use dolasetron

Take this medication by mouth, with or without food, usually within 1 hour before your cancer chemotherapy or within 2 hours before surgery, or as directed by your doctor.

The usual maximum dose is 100 milligrams.

Not available.

Side effects may range from mild to serious complications. Consult your doctor immediately when you feel the following symptoms: Headache, constipation, tiredness, drowsiness, or dizziness, stomach/abdominal pain, change in amount of urine, vision changes, chest pain, severe dizziness, fainting, slow/fast/irregular heartbeat, fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness.

Seek emergency medical help if you expereince allergies (rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing) or the symptoms mentioned above while taking this drug.

Precautions

Inform your doctor of your allergies (food or drugs), medical conditions and  medical history before taking this drug, especially of: heart problems (e.g., irregular heartbeat), stomach/intestinal problems (e.g., recent surgery, ileus, swelling), kidney disease, QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

Older adults may have increased sensitivity to side effects.

For pregnant and nursing (breastfeeding) women, consult your doctor before using this medication.

 

Interactions

Some products that may interact with this drug include: apomorphine, drugs that can slow the heart rate (such as beta blockers including atenolol, calcium channel blockers including verapamil), cimetidine, previous treatment with certain chemotherapy drugs (anthracyclines such as daunorubicin/doxorubicin), rifamycins (e.g., rifampin), dofetilide, pimozide, procainamide, amiodarone, quinidine, ziprasidone, sotalol, macrolide antibiotics (such as erythromycin), MDMA/”ecstasy,” St. John’s wort, certain antidepressants (including SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately.

Missed Dose

Tell your doctor if you forget to take your dose at the correct time before your scheduled chemotherapy appointment or surgery.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Discard the drug properly- do not throw in toilet or sink.

 

Brands:

There are no brands containing this molecule.

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