HUMAN PAPILLOMAVIRUS 9-VALENT VACCINE

Distigmine bromide

Distigmine bromide is a drug that is used to treat myasthenia gravis and other disorders. It is a quaternary ammonium compound that is a reversible cholinesterase inhibitor. It improves the activity of acetylcholine by promoting tonicity and peristalsis in the gastrointestinal tract, as well as increases the wall tension of urinary bladder, sphincter, ureter and the skeletal muscles. It also decreases intraocular pressure.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Distigmine bromide is used in the following conditions:

 

  • Myasthenia gravis
  • Postoperative urinary retention
  • Postoperative gastrointestinal atony
  • Neurogenic bladder disorders
  • Megacolon
  • Chronic hypotonic constipation

 

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Distigmine bromide in people with the following conditions:

 

  • Obstructive and/or spastic conditions of the intestinal tract
  • Biliary or urinary tract
  • Iritis
  • Bronchial asthma
  • Severe hypotonia
  • Myotonia
  • Tetany
  • Epilepsy
  • Thyrotoxicosis
  • Decompensated cardiac insufficiency
  • Arrhythmias
  • Parkinson’s disease

Distigmine bromide may have the following side effects:

 

  • Bradycardia
  • Ventricular tachycardia
  • Angina
  • Arrhythmia
  • Miosis
  • Lacrimation
  • Cycloplegia
  • Blurred vision
  • Nausea
  • Vomiting
  • Abdominal pain
  • Diarrhea
  • Increased salivation
  • Muscle spasm
  • Weakness
  • Fascination
  • Skeletal muscle paralysis
  • Dizziness
  • Drowsiness
  • Headache
  • Dysarthria
  • Grand mal seizures
  • Hypersecretion in the respiratory tract
  • Hypotension

 

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

 

  • Gastric ulcer
  • Duodenal ulcer
  • Bradycardia
  • Hypotension
  • Enteritis
  • Obstruction of the digestive tract or urinary tract
  • Vagotonia
  • Recent intestinal and bladder surgery
  • Hyperthyroidism
  • Pregnancy
  • Lactation

 

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

 

 

Interactions

 

Distigmine bromide may interact with the following medicines:

 

  • Anticholinergics
  • Tricyclic antidepressants
  • Neuroleptics
  • Lithium
  • Nondepolarizing muscle relaxants
  • Antihistamines
  • Aminoglycoside antibiotics
  • Antiarrhythmic agents
  • Beta-blockers
  • Glucocorticoids
  • Dipyridamole

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Symptoms of overdose may include the following:

  • Cholinergic crisis characterised by excessive sweating
  • Lacrimation
  • Miosis
  • Ciliary spasm
  • Nystagmus
  • Increased peristalsis
  • Involuntary defecation and urination
  • Bradycardia
  • Hypotension
  • Muscle cramps
  • Fasciculation
  • Weakness
  • Paralysis
  • Tight chest
  • Wheezing
  • Bronchoconstriction
  • Bradycardia
  • Blood pressure drop
  • Bronchospasm
  • Paradoxical tachycardia
  • Ataxia
  • Convulsions
  • Coma
  • Slurred speech
  • Restlessness
  • Agitation
  • Fear

 

Seek medical help immediately.

Available Brands:

  • Adcostigmine
  • Distigmine Bromide
  • Ubretid
  • Ubretid 0.5%
  • Ubretid 1%
  • Ubretid 5mg

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