After treatment with digoxin immune fab, the serum potassium concentration may drop rapidly and must be monitored frequently, especially over the first several hours after digoxin immune fab is given.
Patients with intrinsically poor cardiac function may deteriorate from withdrawal of the inotropic action of digoxin. When needed, additional support can be provided by use of intravenous inotropes, such as dopamine or dobutamine, or vasodilators. One must be careful in using catecholamines not to aggravate digitalis toxic rhythm disturbances. Clearly, other types of digitalis glycosides should not be used in this setting.
Redigitalization should be postponed, if possible, until the Fab fragments have been eliminated from the body, which may require several days. Patients with impaired renal function may require a week or longer.
Some MEDICINES MAY INTERACT with digoxin immune fab. However, no specific interactions with digoxin immune fab are known at this time.