Description: Dexpanthenol is an alcoholic analogue of D-pantothenic acid. Pantothenic acid is then converted to acetylcholine and maintain the normal function of the intestines.
Description: Dexpanthenol is an alcoholic analogue of D-pantothenic acid. Pantothenic acid is then converted to acetylcholine and maintain the normal function of the intestines.
Indications:
This is used as a prophylaxis immediately after major abdominal surgery to minimize the possibility of paralytic ileus, intestinal atony causing abdominal distention, postoperative or postpartum retention of flatus, or postoperative delay in resumption of intestinal motility.
How to use dexpanthenol:
Prevention of post-operative adynamic ileus: 250 mg (1 mL) or 500 mg (2 mL) intramuscularly. Repeat in 2 hours and then every 6 hours until all danger of adynamic ileus has passed.
Treatment of adynamic ileus: 500 mg (2 mL) intramuscularly. Repeat in 2 hours and then every 6 hours as needed.
Intravenous administration: Dexpanthenol Injection 2 mL (500 mg) may be mixed with bulk I.V. solutions such as glucose or Lactated Ringer’s and slowly infused intravenously.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
Not available.
There have been a few reports of allergic reactions and single reports of several other adverse events in association with the administration of Dexpanthenol.
Symptoms of allergic reactions may include:
Precautions:
If any signs of a hypersensitivity reaction appear, Dexpanthenol Injection should be discontinued. If ileus is a secondary consequence of mechanical obstruction, primary attention should be directed to the obstruction.
The management of adynamic ileus includes the correction of any fluid and electrolyte imbalance (especially hypokalemia), anemia and hypoproteinemia, treatment of infection, avoidance where possible of drugs, which are known to decrease gastrointestinal motility and decompression of the gastrointestinal tract when considerably distended by nasogastric suction or use of a long intestinal tube.
Interactions:
Dexpanthenol may prolong the action of succinylcholine.
Not available.
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