DESERPIDINE

Deserpidine is a drug that causes depletion of noradrenaline stores in sympathetic nerves. It also causes the depletion of catecholamine and serotonin stores in the brain, heart, and in other organs. This further results to a decrease in blood pressure and heart rate and further gives rise to central nervous system depression. There is also decreased cardiac output and peripheral resistance in the blood vessels.

Uses

Deserpidine is used in the treatment of:

Dyskinesias
Hypertension
Schizophrenia

Warnings

Do not use Deserpidine in the following conditions:

Patients receiving electroconvulsive therapy
Depression or a history of depression
Active peptic ulcer or ulcerative colitis
Parkinson’s disease

Side Effects

Deserpidine may have the following side effects:

Nasal congestion
Headache
Central nervous system symptoms
Gastrointestinal disturbances
Respiratory distress
Cyanosis
Anorexia and lethargy may occur in infants whose mothers have received deserpidine prior to delivery
Flushing
Bradycardia
Severe depression
Extrapyramidal effects
Breast engorgement
Galactorrhoea
Gynaecomastia
Increased prolactin concentrations
Decreased libido
Impotence
Sodium retention
Edema
Decreased or increased appetite
Weight gain
Miosis
Dry mouth
Sialorrhoea
Dysuria
Rashes
Pruritus
Thrombocytopaenic purpura

Precautions

Precautions

Extra caution should be observed in people with the following conditions:

Debilitated or elderly patients
Cardiac arrhythmias
Heart attack
Kidney problems
Gallstones
Epilepsy
Allergic conditions
Pheochromocytoma

Interactions

Deserpidine may interact with the following medicines:

Adrenaline
Sympathomimetics
Thiazide diuretics
Other antihypertensives
MAOIs
Digitalis
Quinidine
Central nervous system depressants

Overdose & Brands

If you think you may have overdosed with Deserpidine, seek medical help immediately.

Available Brands:

Aescin, beta-Escin, Canescin, Deresperine, Enduronyl, Harmonyl, Raunorine, Raunormin, Recanescin, Reserpidine, Tranquinil