CLARITHROMYCIN

Clarithromycin is a macrolide antibiotic that binds specifically to the 50S ribosomal subunit of susceptible bacteria, preventing the activation of amino acid transport, hence inhibiting intracellular protein production.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Uses

Clarithromycin is used in the following conditions:

H. pylori eradication in patients with peptic ulcer disease
Infections caused by Mycobacterium Avium Complex (MAC)
Soft tissue and skin infections
Respiratory tract infections

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Warnings

Do not use Clarithromycin in people with the following conditions:

Severe renal impairment (CrCl 30 mL/min)
Serious hepatic failure accompanied with renal insufficiency
Ventricular cardiac arrhythmia, including torsades de pointes
QT prolongation history
Hypokalemia
Previous clarithromycin usage that has been linked to hepatic impairment and cholestatic jaundice
Clarithromycin or any macrolide antibiotic hypersensitivity

Side Effects

Clarithromycin may have the following side effects:

Vasodilation (IV)
Hyperhidrosis
Rash
Insomia
Headache
Increased BUN
Prolonged prothrombin time
Candidiasis
Injection site reactions
Dyspepsia
Dysgeusia
Vomiting
Nausea
Diarrhea
Abdominal pain
Exacerbation or new onset of myasthenia gravis
Hepatic dysfunction

Potentially Fatal:

IgA vasculitis or Henoch-Schonlein purpura
Drug rash with eosinophilia and systemic symptoms
Toxic epidermal necrolysis
Stevens-Johnson syndrome
Acute generalized exanthematous pustulosis
Anaphylaxis
Arrhythmias
QT prolongation
C. Difficile-associated diarrhea (CDAD)
Pseudomembranous colitis
Hepatic failure

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

Lactation
Pregnancy
Children
Hepatic and moderate to serious renal dysfunction
Patients with renal impairment receiving ritonavir or atazanavir- containing regimens at the same time
Patients using drug that is believed to lengthen the QT interval
Myasthenia gravis
Hypomagnesaemia
Conduction disturbances
Clinically significant bradycardia
Serious heart failure
Patient suffering from coronary artery disease

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Clarithromycin may interact with the following medicines:

Triazolam
Diltiazem
Amlodipine
Verapamil
Saquinavir
Itraconazole
Atazanavi
Clarithromycin
Zidovudine
Disopyramide
Quinidine
Tolterodine
Valproate
Theophylline
Vinblastine
Tacrolimus
Sirolimus
Sildenafil
Quetiapine
Omeprazole
Methylprednisolone
Ciclosporin
Cilostazol
Arbamazepine
Alprazolam
Fluconazole
Etravirine
Rifapentine
Rifabutin
Nevirapine
Efavirenz
Phenobarbital
Carbamazepine
Phenytoin
Rifampicin
Warfarin
Insulin
Nateglinide
Repaglinide
Sulfonylureas

Potentially Fatal:

Ticagrelor
Ranolazine
Colchicine
Simvastatin
Lovastatin
Lomitapide
Oral midazolam
Dihydroergotamine
Ergotamine
Astemizole
Terfenadine
Domperidone
Pimozide
Cisapride

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Overdose & Brands

Symptoms of overdose may include the following:

Diarrhea
Nausea
Vomiting
Abdominal pain

Seek medical help immediately.

Available Brands:

RiteMED Clarithromycin
Klaz 250/Klaz Suspension
Klaryz
Klaryth
Klarimed
Klarid
Klaricid/Klaricid OD
Claryn
Claryl
Clarithro-Natrapharm Suspension
Clarithrocid
Clarimid
Clariget/Clariget OD
Clarie DS 125/Clarie DS 250