BUTORPHANOL

Do not use this drug:

• If you are allergic to any ingredient in Butorphanol solution
• If you have had a severe allergic reaction (severe rash, hives, breathing difficulties, or dizziness) to Morphine or Hydromorphone
• If you are taking sodium oxybate (GHB)
• Along with alcohol
• If you have diarrhea due to poisoning, difficulty breathing, or pseudomembranous colitis
• If you have history of narcotic drug dependence

Common side effects may include:

• Confusion
• Constipation
• Dizziness
• Dry Mouth
• Excessive Drowsiness
• Headache
• Itching
• Nausea
• Rash
• Seizures
• Sleepiness or Sleeplessness
• Stuffy Nose
• Sweating

Notify your doctor promptly if any of these symptoms persist or worsen.

Your doctor may have prescribed this medication because he or she judged that the benefit to you is greater than the risk of side effects.

Serious side effects may include:

Severe Allergic Reactions (Rash; Hives; Itching; Difficulty Breathing; Tightness in the Chest; Swelling of the Mouth, Face, Lips, or Tongue)

• Chest Pain
• Excessive Confusion
• Excessive Drowsiness
• Fainting
• Ringing in the Ears
• Seizures
• Slow or Difficult Breathing
• Slow or Irregular Heartbeat
• Vomiting

Precautions

Before taking this drug, tell your doctor or pharmacist:

• If you are allergic to any content of this drug or if you have other allergies.
• If you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
• If you are pregnant or breastfeeding.
• if you certain medical conditions such as:
  • Stomach Problems
  • Prostate Problems
  • Asthma or other Breathing Problems
  • Heart Problems
  • Liver Disease
  • High Blood Pressure
  • An Underactive Thyroid
  • Increased Pressure on the Brain or a Brain Lesion
  • Thoughts of Suicide
  • Seizures
  • Bowel Problems
  • Urinary Problems
  • Recent Heart Attack, Surgery, or Trauma

• if you have a history of substance abuse or dependence

Interactions

Drug interactions may either lessen the effectiveness of this drug or heighten the risk for severe side effects. It’s important to inform your doctor all the medication including prescription and non-prescription and herbal medicines you are taking or going to take.

Possible interactions with this drug are:

• Naltrexone
• Rifampin
• Cimetidine
• Ketorolac
• Barbiturate Anesthetics (eg, Thiopental)
• Sodium Oxybate (GHB)
• Methadone
• Mexiletine

Call emergency hotline if someone has overdosed and has serious symptoms such as passing out or trouble breathing.

Symptoms of overdose may include:

• Cold and Clammy Skin
• Deep Sleep
• Dizziness
• Drowsiness
• Lightheadedness
• Loss of Consciousness
• Slowed Breathing
• Slowed Heartbeat

Available brand/s:

• Orfadol
• Ziphanol