Benzathine benzylpenicillin is a drug which is known to be an antibioitic. It is said to interfere with bacterial cell wall synthesis and further causes bacterial cell death. Its effects usually last for 1 to 4 weeks.

Benzathine benzylpenicillin is used in the following medical conditions:

  • Streptococcal pharyngitis
  • Rheumatic fever
  • Syphilis and Treponemal infections

Benzathine benzylpenicillin should not be given to those with hypersensitivity to penicillins.

Benzathine benzylpenicillin may have the following side effects:

  • Hypersensitivity reactions including skin eruptions
  • Urticaria
  • Laryngeal oedema
  • Serum sickness-like reactions
  • Allergic vasculitis
  • Pruritus
  • Fatigue
  • Asthenia
  • Pain
  • Headache
  • Fever
  • Haemolytic anaemia
  • Leucopenia
  • Thrombocytopenia
  • Neuropathy
  • Nephropathy
  • Hypotension
  • Tachycardia
  • Palpitations
  • Pulmonary hypertension
  • Pulmonary embolism
  • Vasodilation
  • Vasovagal reaction
  • Cerebrovascular accident
  • Syncope
  • Nausea
  • Vomiting
  • Intestinal necrosis
  • Blood in stool
  • Intestinal necrosis
  • Lymphadenopathy
  • Injection site reactions (e.g. pain, inflammation)
  • Joint disorder
  • Periostitis
  • Exacerbation of arthritis
  • Myoglobinuria
  • Rhabdomyolysis
  • Nervousness
  • Tremors
  • Dizziness
  • Somnolence
  • Confusion
  • Anxiety
  • Euphoria
  • Transverse myelitis
  • Seizures
  • Coma
  • Hypoxia
  • Apnoea
  • Dyspnoea
  • Diaphoresis
  • Blurred vision
  • Blindness
  • Neurogenic bladder
  • Haematuria
  • Proteinuria
  • Renal failure
  • Impotence
  • Priapism
  • Anaphylaxis
  • Antibiotic-associated pseudomembranous colitis


Extra caution should be taken in patients with the following:

  • Previous hypersensitivity reactions to cephalosporins
  • History of allergy
  • Asthma
  • Seizure disorder
  • Kidney problems

Benzathine benzylpenicillin is not to be used for injection near major peripheral nerves of blood vessels. This medicine should not be used for a long time because of the danger of bacterial or fungal superinfection.



Benzathine benzylpenicillin may interact with the following medicines:

  • Tetracycline
  • Probenecid

If you think you have overdosed, seek medical help immediately.


Available Brands:

  • Zalpen
  • Benzapen
  • YSS

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