BENDROFLUMETHIAZIDE

• Orthostatic hypotension which may result to:
  • syncope and, in some patients with glaucoma, temporary loss of vision.
• Erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis.
• May increase blood sugar, decrease glucose tolerance and have a potentially deleterious effect on the lipid profile.
• May enhance the formation of some types of gallstones.
• Anorexia, gastric irritation, nausea, vomiting, diarrhea, constipation, or abdominal pain, acute cholecystitis, intrahepatic cholestatic jaundice and rare cases of pancreatitis.
• Rare cases of immune-complex hemolytic anemia, aplastic anemia, and thrombocytopenia.
• May induce allergic reactions in patients who are allergic to sulfonamides.
• Mild hypokalemia which may predispose patients to cardiac arrhythmias.
• Metabolic alkalosis, hyponatremia, hypomagnesemia, hypophosphatemia, hypercalcemia, hyperglycemia, hypercholesterolemia, and hyperuricemia.
• Rare cases of hypercalcemia and milk-alkali syndrome (hypercalcemia, metabolic alkalosis, and renal insufficiency).
• Musculoskeletal cramping or spasm.
• Mild, transient dizziness, fatigue, or headache.

Precautions

• Inform your doctor.
  • Allergy to the medication or any allergies.
  • Medical History of gout, kidney or liver problems, lupus, diabetes, asthma, parathyroid problems, high blood cholesterol or lipid levels, or low blood pressure, low blood sodium, chloride, potassium, or magnesium levels; or high blood calcium levels, recent nerve surgery.
• May cause dizziness or drowsiness. Limit alcohol intake.
• Should only be used when there is a clear need during pregnancy. If you are planning to be pregnant or think you may be pregnant, discuss the risks and benefits of use with your doctor.
• Do not breast-feed while taking bendroflumethiazide as this medication passes into breast milk and may cause unwanted effects on your baby.

Interactions:

Taking multiple drugs may affect how medications work and/or cause unwanted side effects. List down all the medications you are taking and inform your physician and pharmacist. Do not take, discontinue, or alter any dose of medications without prior approval of your physician.

• Products that may interact with this medication include:
  • Nonsteroidal anti-inflammatory medicines (NSAIDs) (eg, ibuprofen) \
  • Barbiturates (eg, phenobarbital), corticosteroids (eg, prednisone), corticotropin (ACTH), narcotic pain medicines (eg, codeine, morphine, fentanyl), or medicines for high blood pressure.
  • Diazoxide or nondepolarizing muscle relaxants (eg, tubocurarine) because side effects.
  • Lithium because the risk of toxicity.
  • Digoxin, dofetilide, or ketanserin because the risk of irregular heartbeat.
  • Diabetes medicines (eg, glipizide, metformin) or insulin.

If overdose is suspected, contact a poison control center or emergency room immediately.

Symptoms may include:

• dry mouth; excessive urination followed by a decrease in amount of urine; muscle cramps; severe lightheadedness, especially upon standing; weak or irregular heartbeat.

Storage:

• Room temperature between 20 and 25 degrees C
• Do not expose to light and moisture
• Do not store in the bathroom
• Keep all medications away from pets and children