HUMAN PAPILLOMAVIRUS 9-VALENT VACCINE

BEMIPARIN SODIUM

Bemiparin sodium is a low molecular weight heparin obtained by depolymerisation of heparin Na from porcine intestinal mucosa. Its anti-Xa activity ranges from 80-120 anti-Xa IU/mg and its anti-IIa activity ranges from 5-20 anti-IIa IU/mg, respectively. Without raising the risk of bleeding, its high anti-Xa/IIa ratio can lead to a higher antithrombotic effect.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Bemiparin sodium is used in the following conditions:

  • Prophylaxis of clotting in the extracorporeal circulation during haemodialysis
  • Prophylaxis of venous thromboembolism during surgical procedures
  • Deep vein thrombosis

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.  

Do not use Bemiparin sodium in people with the following conditions:

  • Hypersensitivity to bemiparin sodium, heparin, and substances of porcine origin
  • History of confirmed or suspected immunologically mediated heparin induced thrombocytopenia (HIT)
  • Active hemorrhage or increased risk of bleeding due to impaired hemostasis
  • Severe pancreatic impairment
  • Injuries to or operations on CNS, eyes, and ears (within the last 2 months)
  • Disseminated intravascular coagulation (DIC) associated with HIT
  • Acute bacterial and slow endocarditis
  • Hemorrhagic stroke
  • Active peptic ulcer
  • Cerebral aneurysm or neoplasms
  • Severe hepatic impairment

Bemiparin sodium may have the following side effects:

  • Severe bleeding
  • Hyperkalemia (reversible)
  • Cutaneous necrosis
  • Mild and transient thrombocytopenia (type I)
  • Rarely, antibody-mediated severe thrombocytopenia (type II) 
  • Bleeding complications (skin, mucous membranes, wounds, gastrointestinal and urogenital tracts)
  • Ecchymosis
  • Hematoma
  • Pain at injection site
  • Mild and transient increase of AST, ALT, and gamma-glutamyl transferase levels
  • Urticaria
  • Pruritus
  • Fever
  • Nausea
  • Vomiting
  • Dyspnea
  • Bronchospasm
  • Glottis edema
  • Hypotension
  • Osteoporosis (long-term use)

Potentially Fatal: 

  • For patient undergoing epidural/spinal anesthesia or lumbar puncture
  • Rarely, epidural and spinal hematoma leading to neurological impairment (prolonged or permanent paralysis)

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Patient with uncontrolled arterial hypertension
  • History of gastro-duodenal ulcer disease
  • Thrombocytopenia
  • Nephrolithiasis or urethrolithiasis
  • Choroid and retinal vascular disease
  • Diabetes mellitus
  • Patient undergoing spinal or epidural anesthesia and/or lumbar puncture 
  • Hepatic and mild to moderate (CrCl 30-80 mL/min) renal impairment
  • Pregnancy
  • Lactation

Prior in taking this medicine, tell your physician or pharmacist if you have allergies  or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Bemiparin sodium may interact with the following medicines:

  • Vitamin K antagonists
  • Anticoagulants
  • Aspirin
  • NSAIDs
  • Ticlopidine
  • Clopidogrel
  • Platelet inhibitors
  • Systemic glucocorticoids
  • Dextran
  • Glyceryl trinitrate
  • Potassium-sparing diuretics

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If an overdose is suspected, call your health care provider immediately.

Available brands:

  • Badyket
  • Entervit
  • Hepadrem
  • Heporax
  • Hibor
  • Ivor
  • Ivormax
  • Phivor
  • Zibor

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