BELIMUMAB

Belimumab is a drug that is also known as a monoclonal antibody that restrains the attachment B-lymphocyte protein to receptors on B-lymphocytes, thus averting B-lymphocytes survival and diminishing the activity of B-cell mediated immunity and autoimmune reactions. Lupus is a severe and probably deadly autoimmune condition that can affect almost all parts of the body. Belimumab is the only drug and biological agent for the treatment of systemic lupus erythematosus. It works by reducing the effects of a specific protein that increases in patients with active lupus. Treatment may reduce the symptoms of SLE.

Uses

Belimumab is used in the following conditions:

Adjunctive therapy in active, autoantibody-positive systemic lupus erythematosis

Warnings

Do not use Belimumab in people with the following conditions:

- Administration of live vaccines

Side Effects

Side Effects

These are the common side effects of Belimumab:

Vomiting
Diarrhea
Stomachache
Fever
Insomnia or problems in sleeping
Depression
Nausea
Headache (migraine)
UTI (urinary tract infection)

Consult a doctor if you are experiencing these side effects:

Mood swings
Chest pain
Weight loss
Unusual tiredness

All side effects are not completely listed here, so if you are experiencing unusual changes in your body, tell your doctor about them.

Precautions

Take extra caution in patients with the following medical conditions:

Patient with severe or chronic infections
History of malignancy
Patient with severe active lupus nephritis and or severe active CNS lupus
HIV
History or current hepatitis B or C
Hypogammaglobulinaemia
History of major organ transplant

You should discuss with your doctor about your other conditions before taking this drug. The first thing that your doctor should know is about your allergies. The drug may contain some substances that can trigger allergies. Also, tell your doctor if you have recent infections so that he or she can treat it. Mood swings such as anxiety or depression should also be considered before taking this medication. Lastly, tell your doctor if you have a history of cancers.

There may be changes in how your medication works. In some cases, some drugs can increase the risk of side effects. Talk to your doctor about the other medicines that you are using, such as vitamins, other maintenance medicines, and herbal products.

Interactions

Belimumab may interact with the following medicines:

May enhance the adverse toxic effect of live vaccines

Overdose & Brands

If you think you have used Belimumab more than the usual dosage, please seek medical help immediately.

Available Brands:

Benlysta