Bactacin is a combination of ampicillin and sulbactam.

Ampicillin prevents bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins resulting in the inhibition of the final transpeptidation step of peptidoglycan synthesis in the bacterial cell walls.

Sulbactam extends the spectrum of ampicillin activity due to its irreversible inhibition of β-lactamases that are found in penicillin-resistant organisms. It has a limited antibacterial activity to Neisseriaceae.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully. 

Your physician’s medication dose is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage; take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages. 

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. Take it at a fixed time every day to make you remember it better. 

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions. 

If you have any inquiries regarding information, ask your physician or pharmacist.

Bactacin is used in the following conditions:

  • Bone and joint infections
  • Lower respiratory tract infections
  • Upper respiratory tract infections
  • Pyelonephritis
  • Urinary tract infection
  • Intra-abdominal infections
  • Gynecological infections
  • Bacterial septicemia
  • Skin and skin structure infections

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.  

Do not use Bactacin in people with the following conditions:

  • History of cholestatic jaundice
  • Hypersensitivity 
  • Hepatic dysfunction associated with ampicillin/sulbactam combination use.

BACTACIN may have the following side effects:

  • Fungal or bacterial superinfection
  • Thrombophlebitis
  • Fatigue
  • Toxic epidermal necrolysis
  • Malaise
  • Pruritus
  • Conjugated estrone
  • Acute generalized exanthematous pustulosis
  • Headache
  • Vomiting
  • Phlebitis
  • Chest pain
  • Neutropenia
  • Leucopenia
  • Hyperbilirubinemia
  • Estradiol
  • Eosinophilia
  • Decreased plasma concentration of total conjugated estriol
  • Abdominal distension
  • Dermatitis exfoliative
  • Diarrhea
  • Estriol-glucuronide (in pregnant women).
  • Urine retention
  • Inj site pain
  • Increased ALT
  • Erythema multiforme
  • Glossitis
  • Anemia
  • Dysuria
  • Flatulence
  • Nausea
  • Thrombocytopenia
  • Chills
  • Mucosal bleeding
  • Epistaxis
  • Throat tightness
  • Edema
  • SJS

Potentially Fatal:

  • Hepatitis
  • Anaphylaxis
  • Cholestatic jaundice

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling of the face or tongue or throat, dizziness or difficulty breathing. 

This is not a complete list of side effects. Contact your physician or pharmacist if you see other effects not recorded above.

Take extra caution in patients with the following medical conditions:

  • Neonates, infants, and children
  • Patient with a history of atopic allergy
  • Infectious mononucleosis
  • Pregnancy and lactation
  • Renal and hepatic impairment

Before taking this medicine, tell your physician or pharmacist if you are allergic to it or if you have some other hypersensitivities. This drug may contain inert ingredients, which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.


Bactacin may interact with the following medicines:

  • Allopurinol
  • Probenecid
  • Methotrexate
  • Anticoagulants
  • Bacteriostatic drugs (e.g. chloramphenicol, erythromycin, sulfonamides, tetracyclines)
  • Aminoglycosides 

Inform your physician about the drugs you take, including over-the-counter medications, prescribed drugs, supplements and vitamins. 

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details. 

The effects of certain medications can change if you simultaneously consume different medications or herbal products. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking. 

While utilizing this drug, don’t start, stop, or change the dose of other medicines you use without your physician’s advice.

Symptoms of overdose may include the following: 

  • CNS dysfunctions
  • Kidney failure
  • Hepatic damage
  • Seizure

Seek medical help immediately. 

Available Brands:

  • Sulbacin
  • Amsul
  • Ciltamin
  • Ampimax
  • Biocillin Plus 750
  • Silgram
  • Ampisul

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