AZACITIDINE - Uses, Warnings,Side Effects,Precautions,Overdose
DROTAVERINE

AZACITIDINE

Azacitidine is an anti-cancer drug that works by blocking the DNA methyltransferases which integrates the synthesis of DNA in mammalian cells thus losing a methyl group. This demethylation agent kills the abnormal cells in the bone marrow and helps in the production of normal blood cells.

 

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully. 

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages. 

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day. 

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions. 

If you have any inquiries with regards to information, ask your physician or pharmacist.

Azacitidine is used in the following conditions:

  • Myelodysplastic disease.

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.  

Do not use Azacitidine in people with the following conditions:

  • Advanced malignant hepatic tumors. 
  • Pregnancy
  • Lactation

Azacitidine may have the following side effects:

  • Nausea and vomiting
  • Anaemia
  • Neutropenia
  • Thrombocytopenia
  • GI or intracranial haemorrhage
  • Hepatotoxicity
  • Renal tubular acidosis
  • Elevated serum creatinine
  • Inj site reactions (e.g. erythema, pain)
  • Insomnia
  • Headache
  • Fatigue
  • Dizziness
  • Anxiety
  • Abdominal pain
  • Anorexia
  • Constipation
  • Diarrhoea
  • Dyspepsia
  • Mucositis
  • Dyspnoea
  • Elevated LFT
  • Hypokalaemia
  • Bruising
  • Petechiae
  • Rash
  • Itch
  • Alopecia
  • Infection
  • Hypersensitivity reactions
  • Fever

Potentially Fatal: 

  • Progressive hepatic coma
  • Renal failure
  • Tumour lysis syndrome 
  • Necrotising fasciitis

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing. 

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Patient with high tumour burden
  • History of severe congestive heart failure
  • Clinically unstable cardiac disease or pulmonary disease
  • Renal and severe hepatic impairment.

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Azacitidine is shown not to interact with medicines.

This article does not contain all possible drug interactions because it may change how your medications work or increase your risk for serious side effects.  Keep a list of all the products you use and consult it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins. 

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details. 

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking. 

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Symptoms of overdose may include the following:

  • Nausea
  • Vomiting
  • Diarrhoea

Seek medical help immediately. 

Available Brands:

  • Vidaza
  • Onureg

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