Aspirin is a salicylate that treats pain and reduces fever or inflammation. Caffeine is a stimulant and works by relaxing the muscle contractions in blood vessels to improve blood flow. Orphenadrine is a muscle relaxant that works by blocking the pain sensations that are sent to the brain.

This combination medication is used to relieve pain and muscle spasms. It is usually used along with rest, physical therapy, and other treatment.

Do not use this drug:

  • Along with alcohol or other drugs that can cause dizziness.
  • If you are allergic to Aspirin, Caffeine, or Orphenadrine.
  • To children under 12 years unless specifically prescribed by the doctor.

Common side effects may include:

  • Drowsiness or Dizziness
  • Headache
  • Tremor
  • Blurred Vision or Large Pupils
  • Difficulty Urinating
  • Hiccups
  • Faint Ringing in the Ears
  • Nausea
  • Vomiting
  • Constipation

Notify your doctor promptly if any of these symptoms persist or worsen.

Your doctor may have prescribed this medication because he or she judged that the benefit to you is greater than the risk of side effects.

Serious side effects may include:

  • Severe Allergic Reaction (Difficulty Breathing; Closing of the Throat; Swelling of the Lips, Tongue, or Face; or Hives)
  • An Irregular or a Very Fast Heartbeat
  • Confusion, Hallucinations, or Abnormal Behaviour
  • Red, Black, or Bloody Stools
  • Blood in Vomit

Seek immediate medical attention if you experience any of these serious side effects.


Before taking this drug, tell your doctor or pharmacist:

  • If you are allergic to any content of this drug or if you have any other allergies.
  • If you are pregnant or breastfeeding.
  • If you are a child who has a fever, flu symptoms, or chicken pox. Consult with your doctor first.
  • Your medical condition or history, especially of:
    • Kidney Disease
    • Liver Disease
    • A Stomach or Intestinal Ulcer or Obstruction
    • A Bleeding or Blood Clotting Disorder
    • Glaucoma
    • An Enlarged Prostate or a Blockage of the Urinary Tract (Difficulty Urinating)
    • Myasthenia Gravis



Drug interactions may either lessen the effectiveness of this drug or heighten the risk for severe side effects. It’s important to inform your doctor all the medication including prescription and non-prescription and herbal medicines you are taking or going to take.


Possible interactions with this drug are:

  • Anti-Platelet Drugs (such as Clopidogrel)
  • “Blood Thinners” (such as Dabigatran, Enoxaparin, Warfarin)
  • Nsaids (such as Ibuprofen, Ketorolac)
  • Alcohol
  • Antihistamines (such as Cetirizine, Diphenhydramine)
  • Drugs for Sleep or Anxiety (such as Alprazolam, Diazepam, Zolpidem)
  • Muscle Relaxants
  • Narcotic Pain Relievers (such as Codeine)

This medication may interfere with certain laboratory tests such as dipyridamole-thallium imaging tests and certain urine tests. Make sure laboratory personnel and all your doctors know you use this drug to avoid false results.

Call emergency hotline if someone has overdosed and has serious symptoms such as passing out or trouble breathing.

Symptoms of overdose may include:

  • Unusual Excitement
  • Fast or Irregular Heartbeat
  • Seizures
  • Rapid Breathing
  • Mental or Mood Changes (such as Confusion)
  • Change in the Amount of Urine


Available brand/s:

  • Anthrom
  • Asaprim
  • Aspen

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