Asparaginase - Uses, Warnings, Side Effects, Precautions, Overdose


Asparaginase, an anticancer drug, lessens L-asparagine levels by catalyzing the deamidation of amino acid to ammonia and aspartic acid. This leads to hindered growth of leukemic cells, which need asparagine synthetase and rely on external asparagine. This drug is obtained  from E coli as the enzyme colaspase (unconjugated) and as pegaspargase (conjugated with polyethylene glycol), or from Erwinia chrysanthemi as crisantaspase.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Asparaginase is used in the following conditions:

  • Acute lymphoblastic leukaemia

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Asparaginase in people with the following conditions:

  • History of serious pancreatitis
  • Hypersensitivity
  • Serious thromboticdisease
  • Haemorrhagic events related to asparaginase therapy
  • Lactation

Severe hepatic impairment

Asparaginase may have the following side effects:

  • Hyperglycemia
  • Abnormal transaminase level
  • Hyperbilirubinemia
  • Local reactions
  • Nausea
  • Vomiting
  • Abdominal discomfort
  • Diarrhea
  • Fever
  • Rash
  • Dyspnea
  • Bronchospasm
  • Urticaria
  • Hypotension
  • Laryngeal edema
  • Altered blood lipids and cholesterol
  • Hypoalbuminemia
  • Hyperammonemia
  • Uremia
  • Renal failure
  • Drowsiness
  • Depression
  • Lethargy
  • Confusion
  • Dizziness
  • Neurotoxicity
  • Hallucination
  • Seizure
  • Parkinson-like syndrome
  • Myalgia
  • Reactive arthritis
  • Transient bone-marrow depression
  • Marked leucopenia
  • Serious hypersensitivity reactions
  • Acute pancreatitis
  • Hepatotoxicity
  • Thrombosis
  • Coagulopathy
  • Ketoacidosis
  • Hyperthermia


Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Patient with mild pancreatitis
  • Hyperglycemia
  • Hepatic impairment

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.


Asparaginase may interact with the following medicines:

  • Vincristine
  • Corticosteroid
  • Methotrexate
  • Dexamethasone

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If overdose is suspected, call your health care provider immediately.

Available Brands:

  • Kidrolase
  • Elspar

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