Artemether and lumefantrine is an antimalarial drug combination that interacts in the food vacuole of the parasite. They prevent the formation of heme (a toxic byproduct during haemoglobin breakdown) to the nontoxic hemozoin (malarial pigment). Both drugs interfere with the synthesis of nucleic acid and protein.
Artemether is metabolized in the body into the active metabolite dihydroartemisinin (DHA) which are rapid schizonticides. Its endoperoxide property makes it an antimalarial drug.
Lumefantrine is a dichlorobenzylidine derivative effective for the treatment of various types of malaria. The exact mechanism of action of how it works as an antimalarial drug is still unknown, but available sources show that it inhibits the development of beta-hematin by forming a complex with hemin.
Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.
The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.
If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.
Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.
If you have any inquiries with regards to information, ask your physician or pharmacist.