Artemether and lumefantrine is an antimalarial drug combination that interacts in the food vacuole of the parasite. They prevent the formation of heme (a toxic byproduct during haemoglobin breakdown) to the nontoxic hemozoin (malarial pigment). Both drugs interfere with the synthesis of nucleic acid and protein.

Artemether is metabolized in the body into the active metabolite dihydroartemisinin (DHA) which are rapid schizonticides. Its endoperoxide property makes it an antimalarial drug.

Lumefantrine is a dichlorobenzylidine derivative effective for the treatment of various types of malaria. The exact mechanism of action of how it works as an antimalarial drug is still unknown, but available sources show that it inhibits the development of beta-hematin by forming a complex with hemin.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully. 

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages. 

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day. 

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions. 

If you have any inquiries with regards to information, ask your physician or pharmacist. 

Artemether + Lumefantrine is used in the following conditions:

  • Acute uncomplicated falciparum malaria.


This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Artemether + Lumefantrine in people with the following conditions:

  • Hypersensitivity
  • History of sudden death or congenital prolongation of QT interval
  • History of cardiac arrhythmias
  • Bradycardia
  • CHF with reduced left ventricular ejection fraction
  • Electrolyte disturbances (e.g. hypokalaemia, hypomagnesemia)
  • Patients taking drugs known to prolong QT interval

Artemether + Lumefantrine may have the following side effects:

  • Anaemia
  • Splenomegaly
  • Palpitations 
  • QT prolongation 
  • Abdominal pain 
  • Nausea
  • Vomiting
  • Diarrhoea
  • Asthenia
  • Fatigue
  • Fever
  • Malaise
  • Hepatomegaly
  • Malaria
  • Increased serum AST
  • Decreased appetite
  • Arthralgia
  • Chills
  • Myalgia
  • Dizziness
  • Headache
  • Paraesthesia 
  • Clonus
  • Gait disturbance vertigo
  • Sleep disorder
  • Insomnia
  • Cough
  • Rhinitis
  • Pruritus
  • Rash
  • Anaphylaxis (Potentially Fatal)


Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  


A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing. 


This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Severe renal and hepatic impairment
  • Children 
  • Pregnancy and lactation
  • Not indicated for the prevention and treatment of severe or complicated malaria.


Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.



Artemether + Lumefantrine may interact with the following medicines:

  • Hormonal contraceptives
  • CYP3A4 inducers (e.g. phenytoin, carbamazepine, rifampicin)
  • Class I and II (e.g. quinidine, amiodarone)
  • Antipsychotics (e.g. pimozide, ziprasidone)
  • Neuroleptics
  • Antidepressants
  • Antibiotics (e.g. macrolide, fluoroquinolone)
  • Triazole antifungals
  • Non-sedating antihistamines (e.g. terfenadine, astemizole)
  • Cisapride
  • Flecainide
  • Halofrantine


Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins. 


This is not a complete list of drug interactions. Approach your physician or pharmacist for more details. 


The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking. 


While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If an overdose is suspected call your healthcare provider immediately.


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