Arsenic Trioxide - Uses, Warnings, Side Effects, Precautions, Overdose,

Arsenic Trioxide

Arsenic trioxide is a chemotherapeutic or antineoplastic agent which targets the enzyme thioredoxin reductase and causes morphological changes and DNA fragmentation in acute promyelocytic leukemia (APL) cells. It also breaks down and disrupts the fusion of promyelocytic leukemia (PML)-retinoic acid receptor (RAR)-alpha, thus inducing cancer cells to undergo apoptosis.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Arsenic Trioxide is used in the following conditions:

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Arsenic Trioxide in people with the following conditions:

  • Lactation

Arsenic Trioxide may have the following side effects:

  • Leucocytosis
  • Neutropenia
  • Increased liver enzyme values
  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Fatigue
  • Edema
  • Hyperglycemia
  • Hypokalemia
  • Dyspnea
  • Cough
  • Rash
  • Pruritus
  • Pyrexia
  • Headache
  • Paresthesia/Dysesthesia
  • Dizziness
  • Hemorrhage
  • Infection
  • Atrial fibrillation/flutter


Potentially fatal:

  • APL differentiation syndrome
  • QT prolongation leading to torsades de pointes
  • Complete atrioventricular block


Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Patient withhistory of torsades de pointes
  • Pre-existing QT interval prolongation
  • Congestive heart failure
  • Electrolyte abnormalities (hypokalemia, hypomagnesemia)
  • Hepatic and renal impairment
  • Pregnancy


Prior in taking this medicine, tell your physician or pharmacist if you have allergies  or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.



Arsenic Trioxide may interact with the following medicines:

  • Diuretics
  • Amphotericin B
  • Quinidine
  • Amiodarone
  • Sotalol
  • Dofetilide
  • Thioridazine
  • Ziprasidone
  • Pimozide
  • Amitriptyline
  • Erythromycin
  • Terfenadine
  • Astemizole
  • Sparfloxacin
  • Cisapride


Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you think you have used Arsenic trioxide more than the usual dosage, please seek medical help immediately.

Symptoms of overdose may include the following:

  • Convulsions
  • Muscle weakness
  • Confusion


Available Brands:

  • Asadin
  • Trisenox

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