Arenavirus infections are caused by a wide range of viruses that often infect rodents. Arenaviruses are transmitted into the environment by infected rodent hosts via their urine, saliva, or droppings. People get infected when mouse droppings, urine, or nesting materials are disturbed, such as during cleaning. People may also get infected by touching their faces after coming into contact with the virus, by being bitten or scratched by infected rodents, or by eating contaminated food. Arenaviruses may be transmitted to humans in certain cases by eating infected rodents.

The most well-known arenaviruses include lymphocytic choriomeningitis virus (LCMV) and hemorrhagic fevers induced by Machupo virus, Junin virus, and Lassa virus.

Moreover, the rodents that carry arenaviruses may be found all throughout the globe, including Asia, Africa, Europe, and the Americas. Arenavirus infections in humans are rather prevalent in various parts of the globe and may cause serious sickness.


Frequently, arenavirus infections are mild or asymptomatic. Typical symptoms include fever, cough, body pains, headache, and a decrease in white blood cells, followed by a full recovery. In rare instances, the first symptoms include a stiff or painful neck, a rash, and myocarditis. Arenaviridae virus-caused illnesses may be lethal.


Doctors may do the following tests to identify Arenavirus infections:

  • Blood Test: Blood may be examined for viral antibodies or antigens.
  • Cultures: These are microorganisms that are grown in a laboratory from samples of blood, bodily fluid, or other material collected from an affected region until there are enough to identify.
  • Polymerase chain reaction (PCR): These may be used to replicate the virus’s genetic material in large numbers. This method allows clinicians to detect the virus quickly and precisely.
  • An electron microscope, which gives great magnification and good clarity, is occasionally used to examine a sample of blood or other tissues.

When the illness poses a substantial danger to public health or the symptoms are severe, tests are sometimes performed rapidly.


There is no particular therapy for the majority of these conditions. Some diseases, such as Lassa fever, respond to antiviral treatments if administered during the first week of sickness. Supportive care, especially the management of subsequent bacterial infections, may also aid in mortality reduction.

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