Description: Anakinra is an antagonist of interleukin-1.

Anakinra is used to treat rheumatoid arthritis by slowing joint damage and reduces the joint pain/swelling; also used to treat a certain condition called Neonatal-Onset Multisystem Inflammatory Disease (NOMID) and improve symptoms of the disease such as fever, rash, joint pain, vomiting, and headache.

How to use anakinra subcutaneous

This medication is injected under the skin (subcutaneously), usually once a day or as directed by your doctor.

Do not shake this medication, and let it warm to room temperature for 30 minutes before injecting it.  Clean the injection site with rubbing alcohol. Do not inject this medication in an area that is tender, red, bruised, or hard or which has scars or stretch marks.

Do not reuse the syringe. Learn how to store and discard needles and medical supplies safely.

Common side effects include: Redness, bruising, swelling, and pain at the injection site may occur usually mild and may last 2 to 4 weeks.

Serious side effects include: serious infections (such as skin/bone/joint infections, pneumonia), fever/chills, persistent sore throat, cough with mucus, spreading redness/swelling/tenderness of the skin, bone pain.

Contact your doctor if you experience allergic reactions or symptoms mentioned above.


Inform your doctor or pharmacist your allergies, medical history, especially of: current/past/returning infections (such as tuberculosis), immune system problems (such as HIV disease), kidney disease, asthma.

Prevent infection by washing your hands well,  avoiding contact with people who have infections that may spread to others (such as chickenpox, measles, flu), avoiding contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose) and do not have immunizations/vaccinations without the consent of your doctor.

Pregnant and breastfeeding women should take caution, consult your doctor before taking this drug.



Some products that may interact with this drug include: abatacept, tofacitinib, TNF blockers (such as adalimumab, certolizumab, etanercept, infliximab).


Get emergency medical help when overdose is suspected.

Missed Dose: As soon as you remember, take a regular dose or if the time of the next does is near, wait for it before taking another dose and resume your usual schedule.  Do not increase the dose to compensate for the missed dose.

Storage: Store medication in room temperature.  Do not expose to light and moisture. Do not store in the bathroom. Keep all medications away from pets and children.  Do not flush medications down the toilet or pour into a drain.

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