Amphetamine and Dextroamphetamine combination is an amphetamine that works by dealing with certain chemicals in the brain that may affect attention span and behavior.

This combination is used to treat attention-deficit hyperactivity disorder (ADHD) and narcolepsy (uncontrollable desire for sleep or sudden attacks of deep sleep). These two medicines belong to the group of medicines called central nervous system (CNS) stimulants.

Amphetamine/Dextroamphetamine, if used for a long period of time, has a high potential for abuse and may be habit-forming. Use amphetamine/dextroamphetamine only as prescribed and do not share it with others. Abuse of amphetamine/dextroamphetamine may cause serious heart problems, blood vessel problems, or sudden death.

Dextroamphetamine and amphetamine may cause side effects.

Tell your doctor if any of these symptoms persist or worsen:

  • Nervousness
  • Restlessness
  • Difficulty Falling Asleep or Staying Asleep
  • Uncontrollable Shaking of a Part of the Body
  • Headache
  • Changes in Sex Drive or Ability
  • Dry Mouth
  • Stomach Pain
  • Constipation
  • Loss of Appetite
  • Weight Loss

Call your doctor immediately if you experience serious side effects such as:

  • Fast or Pounding Heartbeat
  • Chest Pain or Shortness of Breath
  • Excessive Tiredness
  • Slow or Difficult Speech
  • Dizziness or Faintness
  • Weakness or Numbness of an Arm or Leg or Loss of Coordination
  • Seizures
  • Motor or Verbal Tics
  • Feeling Unusually Suspicious of Others or Hallucinating (Seeing Things or Hearing Voices that do not Exist)
  • Fever
  • Sweating
  • Severe Muscle Stiffness or Twitching
  • Nausea
  • Vomiting
  • Diarrhea
  • Mania (Frenzied or Abnormally Excited Mood)
  • Aggressive or Hostile Behavior
  • Changes in Vision or Blurred Vision
  • Paleness or Blue Color of Fingers or Toes
  • Pain, Numbness, Burning, or Tingling in the Hands or Feet
  • Unexplained Wounds Appearing on Fingers or Toes
  • Blistering or Peeling Skin
  • Itching, Rashes and Hives
  • Swelling of the Eyes, Face, Tongue, or Throat
  • Difficulty Breathing or Swallowing
  • Hoarseness

Dextroamphetamine and Amphetamine may slow children’s growth or weight gain. Talk to your child’s doctor about the risks of giving Dextroamphetamine and Amphetamine to your child.


Some medical conditions may interact with Amphetamine and Dextroamphetamine.

Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • Pregnant, Planning to Become Pregnant, or are Breast-feeding
  • Taking any Prescription or Nonprescription Medicine, Herbal Preparation, or Dietary Supplement
  • Have Allergies to Medicines, Foods, or Other Substances
  • Have a History of Heart Problems (Eg, Heart Failure, Fast Or Irregular Heartbeat), Heart Defects, Recent Heart Attack, High Blood Pressure, Hardening Of The Arteries, or Blood Vessel Problems, or if a Family Member Has a History of Irregular Heartbeat or Sudden Death
  • Have a Historyof Liver or Kidney Problems, Growth Problems, Thyroid Problems, Uncontrolled Muscle Movements (Eg, Tics), Tourette Syndrome, Anorexia, or the Blood Disease Porphyria
  • Have a History of Seizures or Abnormal Electroencephalograms (Eegs)
  • Have a History of Mood or Mental Problems (Eg, Agitation, Anxiety, Bipolar Disorder, Depression, Psychosis, Tension), Abnormal Thoughts, Hallucinations, Suicidal Thoughts or Attempts, or Alcohol or Other Substance Abuse or Dependence or if a Family Member has a History of Any of these Problems
  • Have Circulation Problems in Your Hands or Feet (Eg, Raynaud Phenomenon, ThromboangiitisObliterans)



Some medicines may interact with Amphetamine and Dextroamphetamine. Ask your health care provider if Amphetamine and Dextroamphetamine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Some medications that interact with this drug combination are:

  • Furazolidone Or Maois (Eg, Phenelzine)

Side Effects, Such as Increased Blood Pressure, Headache, Fever, and Irregular Heartbeat May Occur

  • Alkalinizing Agents (Antacids, Sodium Bicarbonate, Acetazolamide), Decongestants (Pseudoephedrine), Propoxyphene, Proton Pump Inhibitors (Ppis) (Lansoprazole, Omeprazole) Sympathomimetic Medicines (Eg, Albuterol)

They May Increase the Risk of Amphetamine And Dextroamphetamine’s Side Effects

  • Glutamic Acid, Haloperidol, Lithium Carbonate, Phenothiazines (Chlorpromazine),Ppis (Lansoprazole, Omeprazole), Reserpine, Urinary Acidifiers (Methenamine, Ammonium Chloride), or Vitamin C (Ascorbic Acid)

They May Decrease Amphetamine and Dextroamphetamine’s Effectiveness

  • Meperidine, Norepinephrine, Selective Serotonin Reuptake Inhibitors ( Fluoxetine), Tramadol, Or Tricyclic Antidepressants (Desipramine)

The Risk of their Side Effects may be Increased by Amphetamine and Dextroamphetamine

  • Alpha-Blockers (Eg, Prazosin), Antihistamines (Eg, Diphenhydramine), Beta-Blockers (Eg, Metoprolol), Ethosuximide,Guanadrel, Guanethidine, Medicines For High Blood Pressure, Phenobarbital, or Phenytoin

Their Effectiveness May be Decreased by Amphetamine and Dextroamphetamine

Call local emergency services, in case of overdose or if the victim has collapsed or not breathing.

Symptoms of overdose may include the following:

  • Restlessness
  • Confusion
  • Aggressive Behavior
  • Feelings of Panic
  • Hallucination (seeing things or hearing voices that do not exist)
  • Fast Breathing
  • Uncontrollable Shaking of a Part of the Body
  • Fever
  • Dark Red or Cola-Colored Urine
  • muscle weakness or aching
  • tirednessor weakness
  • Depression
  • Fast or Irregular Heartbeat
  • Fainting
  • Dizziness
  • Blurred Vision
  • Upset Stomach
  • Vomiting
  • Diarrhea
  • Seizures
  • Coma (Loss of Consciousness for a Period of Time)

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