AMITRIPTYLINE

Amitriptyline is a dibenzocycloheptadiene tricyclic antidepressant. It facilitates the inhibition of the neuronal reuptake of the neurotransmitters serotonin (5-HT) and norepinephrine of the presynaptic neuron, therefore, increasing the concentration of both neurotransmitters in the central nervous system. It also carries an affinity for the muscarinic and histamine receptors to differing degrees.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Uses

Amitriptyline is used in the following conditions:

Depression
Neuropathic pain
Nocturnal enuresis
Prophylaxis of migraine

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Warnings

Do not use Amitriptyline in people with the following conditions:

Arrythmia
Children less than 6 yearsold
Concomitant use within 14 days of MAOIs use and cisapride
Coronary artery insufficiency
Recent heart attack
Severe hepatic impairment

Side Effects

Amitriptyline may have the following side effects:

Anorexia
Blurred vision
Bone fractures
Breast enlargement
Central nervoussystem depression
Gynecomastia
Hypertension
Hypotension
Leukopenia
Mydriasis
Edema
Palpitation
Seizures
Tachycardia
Thrombocytopenia/ low platelet count
Tinnitus

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist

Precautions

Precautions

Take extra caution in patients with the following medical conditions:

Behavioural changes and increased risk of suicidal thinking
Concomitant electroconvulsive therapy and elective surgery
CYP2D6 ultrarapid, intermediate and poor metabolisers
Diabetes mellitus
Elderly and children
History of seizures
Hyperthyroidism
Lactation
Paralytic ileus
Paranoid symptomology
Patient with heartdisease
Pregnancy
Pylorus stenosis
Renal and mild to moderate liverimpairment

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Amitriptyline may interact with the following medicines:

Antihistamines
Barbiturates
Betanidine
Clonidine
Central nervous systemdepressants
Fluoxetine
Methyldopa
Reserpine
Selegiline

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Overdose & Brands

If you think you have used Amitriptyline more than the usual dosage, please seek medical help immediately.

You may exhibit the following symptoms in the event of an overdose:

Cardiac dysrhythmias
Central nervous systemdepression
Coma
Convulsions
Excitement
Fever
Hyperreflexia with extensor plantar reflexes
Hypothermia
Respiratory depression
Restlessness with marked antimuscarinic effects including dry mouth, intestinal stasis mydriasis, tachycardia, urinary retention, dry mucous membranes, reduced bowel motility
Severe hypotension

Available Brand:

Tripgen