AMITRIPTYLINE- Uses, Warnings, Precautions,Overdose and Brands


Amitriptyline is a dibenzocycloheptadiene tricyclic antidepressant. It facilitates the inhibition of the neuronal reuptake of the neurotransmitters serotonin (5-HT) and norepinephrine of the presynaptic neuron, therefore, increasing the concentration of both neurotransmitters in the central nervous system. It also carries an affinity for the muscarinic and histamine receptors to differing degrees.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Amitriptyline is used in the following conditions:

  • Depression
  • Neuropathic pain
  • Nocturnal enuresis
  • Prophylaxis of migraine

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Amitriptyline in people with the following conditions:

  • Arrythmia
  • Children less than 6 yearsold
  • Concomitant use within 14 days of MAOIs use and cisapride
  • Coronary artery insufficiency
  • Recent heart attack
  • Severe hepatic impairment

Amitriptyline may have the following side effects:

  • Anorexia
  • Blurred vision
  • Bone fractures
  • Breast enlargement
  • Central nervoussystem depression
  • Gynecomastia
  • Hypertension
  • Hypotension
  • Leukopenia
  • Mydriasis
  • Edema
  • Palpitation
  • Seizures
  • Tachycardia
  • Thrombocytopenia/ low platelet count
  • Tinnitus

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist


Take extra caution in patients with the following medical conditions:

  • Behavioural changes and increased risk of suicidal thinking
  • Concomitant electroconvulsive therapy and elective surgery
  • CYP2D6 ultrarapid, intermediate and poor metabolisers
  • Diabetes mellitus
  • Elderly and children
  • History of seizures
  • Hyperthyroidism
  • Lactation
  • Paralytic ileus
  • Paranoid symptomology
  • Patient with heartdisease
  • Pregnancy
  • Pylorus stenosis
  • Renal and mild to moderate liverimpairment

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.



Amitriptyline may interact with the following medicines:

  • Antihistamines
  • Barbiturates
  • Betanidine
  • Clonidine
  • Central nervous systemdepressants
  • Fluoxetine
  • Methyldopa
  • Reserpine
  • Selegiline

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you think you have used Amitriptyline more than the usual dosage, please seek medical help immediately.

You may exhibit the following symptoms in the event of an overdose:

  • Cardiac dysrhythmias
  • Central nervous systemdepression
  • Coma
  • Convulsions
  • Excitement
  • Fever
  • Hyperreflexia with extensor plantar reflexes
  • Hypothermia
  • Respiratory depression
  • Restlessness with marked antimuscarinic effects including dry mouth, intestinal stasis mydriasis, tachycardia, urinary retention, dry mucous membranes, reduced bowel motility
  • Severe hypotension


Available Brand:

  • Tripgen

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