AMERICAN TRYPANOSOMIASIS

American trypanosomiasis, often known as Chagas disease, is a potentially fatal parasitic infection that is caused by the protozoan parasite Trypanosoma cruzi. The illness is most frequent in Central and South America, Trinidad, and the United States’ southern states. It is, however, less prevalent beyond the rural settings where vectors are abundant in rustic houses. 

The vector-borne illness is transmitted vertically between the mother and the fetus or by contact with infected feces or urine of the reduviid insect (triatomine bug, kissing bug), which acts as an intermediary host for the parasite. Other means of transmission include blood transfusion, transplantation of an infected organ, and ingestion of contaminated food or beverages. Cardiomegaly, gastrointestinal problems, and, in rare cases, peripheral neuropathy are major sequelae of this condition.

TYPES

American trypanosomiasis may induce a short-term (acute) or long-term (chronic) condition.

Although many people don’t develop symptoms until the chronic stage, they can range from minor to severe.

Acute phase

American Trypanosomiasis’ acute phase, which can persist for weeks or months, is frequently symptom-free. Signs and symptoms are often mild and might include:

  • Loss of appetite
  • Swelling
  • Fever
  • Headache
  • Enlargement of your liver or spleen
  • Nausea, diarrhea, or vomiting
  • Fatigue
  • Body aches
  • Swollen glands
  • Rash
  • Eyelid swelling

Chronic phase

Chagas disease chronic symptoms and signs may occur 10-20 years after the initial infection, or they may not appear at all. The following signs and symptoms manifest during the chronic phase:

  • Sudden cardiac arrest
  • Irregular heartbeat
  • Stomach pain 
  • Constipation
  • Difficulty swallowing 
  • Heart failure

DIAGNOSIS

With a quick blood test, your doctor can diagnose Chagas disease—the test checks for antibodies to the parasite.

If you are diagnosed with Chagas disease, you will likely have further examinations. These tests may be performed to evaluate whether the condition has progressed to the chronic stage and has produced cardiac or intestinal issues. Among the possible tests are:

  • Echocardiogram 
  • Electrocardiogram (EKG, ECG)
  • X-ray or CT scan of the abdomen or chest

TREATMENT

Chagas disease treatment focuses on eliminating the parasite and managing symptoms. Benznidazole with nifurtimox (Lampit) may be useful during the acute phase of Chagas disease. Both medications are accessible in Chagas disease-affected locations. 

Once the chronic phase of American trypanosomiasis has set in, no medicine can cure the condition. However, the medications may be prescribed to those under the age of 50 since they may reduce the disease’s course and its most severe effects.

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