ALOGLIPTIN + METFORMIN

Alogliptin + Metformin is a combination drug that is made up of Alogliptin and Metformin, two medicines for diabetes. Alogliptin inhibits the enzyme dipeptidylpeptidase-4 (DPP-4), further increasing incretin hormone levels that leads to decreased glucose production in the liver. Metformin is a biguanide medicine that reduces the production of glucose in the liver and makes the body tissues sensitive to insulin.

Uses

Alogliptin + Metformin is used in the treatment of Type 2 diabetes mellitus.

Warnings

Alogliptin + Metformin should not be given to people with the following conditions:

Acute or chronic metabolic acidosis (example diabetic ketoacidosis, lactic acidosis)
Diabetic pre-coma
Alcoholism or acute alcohol intoxication
Acute or chronic disease that may cause hypoxia (example cardiac or respiratory failure, recent heart attack, shock)
Conditions which may alter kidney function (example severe infection, dehydration)
Intravascular administration of iodinated contrast agents
Liver and kidney disease

Side Effects

Alogliptin + Metformin may give rise to the following side effects:

Abdominal pain
Acute pancreatitis
Back pain
Bullous pemphigoid
Diarrhea
Gastroenteritis
Gastroesophageal reflux disease
Headache
Heart failure
Hepatotoxicity
Hypertension
Hypoglycemia
Lactic acidosis
Liver failure
Nasopharyngitis
Pruritus
Rash
Severe arthralgia
Upper respiratory infection
Urinary tract infection
Vitamin B12 deficiency
Vomiting, gastritis
Rarely, serious hypersensitivity reactions (example anaphylaxis, angioedema, Stevens-Johnson syndrome, exfoliative skin conditions)

Precautions

Precautions

Special precautions should be observed in the following medical conditions:

Patients with history of heart failure
Pancreatitis
Abnormal serum transaminases
Those who are exposed to stress-related states (example infection, fever, trauma, surgery)
Kidney disease
Pregnancy
Lactation

Interactions

Alogliptin + Metformin may interact with the following medicines:

Thiazides and other diuretics
Corticosteroids
Phenothiazines
Thyroid products
Oral contraceptives
Sympathomimetics
Phenytoin
Nicotinic acid
Calcium channel blockers
Isoniazid
Sulfonylureas or insulin
Cationic drugs that interfere with renal tubular transport systems (example ranolazine, vandetanib, dolutegravir, cimetidine)
Topiramate or other carbonic anhydrase inhibitors (example zonisamide, acetazolamide, dichlorphenamide)
ACE inhibitors
Angiotensin II receptor antagonists
NSAIDs
Loop diuretics
Vitamin B12
IV iodinated contrast agents

Overdose & Brands

If you think you may have used Alogliptin + Metformin more than the usual dose, seek medical help immediately.

Available Brands:

Kazano