Alogliptin + Metformin is a combination drug that is made up of Alogliptin and Metformin, two medicines for diabetes. Alogliptin inhibits the enzyme dipeptidylpeptidase-4 (DPP-4), further increasing incretin hormone levels that leads to decreased glucose production in the liver. Metformin is a biguanide medicine that reduces the production of glucose in the liver and makes the body tissues sensitive to insulin.

Alogliptin + Metformin is used in the treatment of Type 2 diabetes mellitus.

Alogliptin + Metformin should not be given to people with the following conditions:

  • Acute or chronic metabolic acidosis (example diabetic ketoacidosis, lactic acidosis)
  • Diabetic pre-coma
  • Alcoholism or acute alcohol intoxication
  • Acute or chronic disease that may cause hypoxia (example cardiac or respiratory failure, recent heart attack, shock)
  • Conditions which may alter kidney function (example severe infection, dehydration)
  • Intravascular administration of iodinated contrast agents
  • Liver and kidney disease

Alogliptin + Metformin may give rise to the following side effects:

  • Abdominal pain
  • Acute pancreatitis
  • Back pain
  • Bullous pemphigoid
  • Diarrhea
  • Gastroenteritis
  • Gastroesophageal reflux disease
  • Headache
  • Heart failure
  • Hepatotoxicity
  • Hypertension
  • Hypoglycemia
  • Lactic acidosis
  • Liver failure
  • Nasopharyngitis
  • Pruritus
  • Rash
  • Severe arthralgia
  • Upper respiratory infection
  • Urinary tract infection
  • Vitamin B12 deficiency
  • Vomiting, gastritis
  • Rarely, serious hypersensitivity reactions (example anaphylaxis, angioedema, Stevens-Johnson syndrome, exfoliative skin conditions)


Special precautions should be observed in the following medical conditions:

  • Patients with history of heart failure
  • Pancreatitis
  • Abnormal serum transaminases
  • Those who are exposed to stress-related states (example infection, fever, trauma, surgery)
  • Kidney disease
  • Pregnancy
  • Lactation



Alogliptin + Metformin may interact with the following medicines:

  • Thiazides and other diuretics
  • Corticosteroids
  • Phenothiazines
  • Thyroid products
  • Oral contraceptives
  • Sympathomimetics
  • Phenytoin
  • Nicotinic acid
  • Calcium channel blockers
  • Isoniazid
  • Sulfonylureas or insulin
  • Cationic drugs that interfere with renal tubular transport systems (example ranolazine, vandetanib, dolutegravir, cimetidine)
  • Topiramate or other carbonic anhydrase inhibitors (example zonisamide, acetazolamide, dichlorphenamide)
  • ACE inhibitors
  • Angiotensin II receptor antagonists
  • NSAIDs
  • Loop diuretics
  • Vitamin B12
  • IV iodinated contrast agents

If you think you may have used Alogliptin + Metformin more than the usual dose, seek medical help immediately.

Available Brands:

  • Kazano

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