ALISKIREN + HYDROCHLOROTHIAZIDE - Uses, Warnings, Side Effects
HUMAN PAPILLOMAVIRUS 9-VALENT VACCINE

ALISKIREN + HYDROCHLOROTHIAZIDE

Aliskiren, an enzyme necessary for the conversion of angiotensinogen into angiotensin I, is a direct inhibitor of renin. It reduces the activity of plasma renin, thereby inhibiting the production of angiotensin II and aldosterone. In distal tubules, hydrochlorothiazide prevents sodium reabsorption, causing increased excretion of sodium and water, including potassium and hydrogen ions.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Aliskerin + Hydrochlorothiazide is used in the following conditions:

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.  

Do not use Aliskerin + Hydrochlorothiazide in people with the following conditions:

  • Hypersensitivity to aliskiren and other sulfonamide-derived drugs
  • Anuria
  • Volume depletion
  • History of angioedema
  • Hereditary or idiopathic angioedema
  • Severe hepatic and renal impairment (GFR <30 mL/min/1.73m2)
  • Concomitant use with ACE inhibitors or angiotensin II receptor antagonists in patient with diabetes mellitus or renal impairment (GFR <60 mL/min/1.73m2)
  • Concomitant use with potent P-glycoprotein (P-gp) inhibitors (e.g. ciclosporin, itraconazole and quinidine)
  • Pregnancy

Aliskerin + Hydrochlorothiazide may have the following side effects:

  • Electrolyte disturbances 
  • Urticaria
  • Gout
  • Hypotension
  • Syncope
  • Acute transient myopia
  • Acute angle-closure glaucoma
  • Photosensitivity
  • Acute renal failure
  • Metabolic disturbances
  • SLE exacerbation or activation
  • Palpitations
  • Diarrhea
  • Decreased appetite
  • Nausea
  • Vomiting
  • Oral mucosal reactions
  • Increased liver enzymes
  • Peripheral edema
  • Arthralgia
  • Dizziness
  • Impotence
  • Cough
  • Rash
  • Stevens Johnson syndrome
  • Toxic epidermal necrolysis
  • Pruritus

Potentially Fatal: 

  • Anaphylactic reactions
  • Angioedema

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

  • Patient with prediabetes or diabetes
  • History or risk for gout
  • History of allergy or bronchial asthma
  • Volume or salt depletion
  • Renal artery stenosis
  • Cardiovascular disease
  • Post myocardial infarction
  • Hypercalcemia
  • Moderate or high cholesterol levels
  • Parathyroid disease
  • Systemic Lupus Erythematosus
  • Mild to moderate renal and hepatic impairment
  • Lactation

Prior in taking this medicine, tell your physician or pharmacist if you have allergies  or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Aliskerin + Hydrochlorothiazide may interact with the following medicines:

Aliskiren:

  • ACE inhibitors
  • Angiotensin II receptor antagonists 
  • NSAIDs
  • Atorvastatin
  • Ketoconazole
  • Verapamil
  • Furosemide 
  • Potassium-sparing diuretics
  • Potassium supplements or any substances that may increase serum potassium levels
  • Lithium
  • Barbiturates
  • Narcotics
  • Corticosteroids
  • ACTH
  • Opioids
  • NSAIDs
  • Carbenoxolone
  • Antidiabetics

Potentially Fatal: 

  • ACE inhibitors
  • Angiotensin II receptor antagonists 
  • Ciclosporin
  • Itraconazole
  • Quinidine

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If an overdose is suspected, call your health care provider immediately.

Available brands:

  • Tekturna HCT

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