ALENDRONATE - Uses Warning Side effects Precautions Overdose & Brands-Watson Health
Watsons Health


Alendronate, also known as alendronic acid, is used in treating osteoporosis, irregular osteogenesis and many other bone-related disorders. It is available orally and also exists as a combination drug with vitamin D.

Osteoclasts are a type of cells that impact bone reabsorption. Alendronate binds to bone hydroxyapatite and blocks osteoclasts’ activity.

Alendronate is used in treating and preventing osteoporosis in women who had menopause. It is also prescribed to increase bone mass in men suffering from osteoporosis.

Do not give Alendronate to people with the following conditions:

  • Hypersensitivity
  • Abnormalities of the esophagus like stricture or achalasia
  • Unable to stand or sit upright for at least 30 minutes
  • Hypocalcemia

Alendronate may have the following side effects:

  • Abdominal pain
  • Nausea
  • Dyspepsia
  • Constipation
  • Diarrhea
  • Flatulence
  • Acid regurgitation
  • Esophageal ulcer
  • Vomiting
  • Dysphagia
  • Abdominal distension
  • Gastritis
  • Gastric ulcer
  • Melena
  • Musculoskeletal (bone, muscle or joint) pain
  • Muscle cramps
  • Headache
  • Dizziness
  • Taste perversion


Take extra caution in patients with the following medical conditions:

  • Heartburn
  • Active upper gastro intestinal problems like dysphagia
  • Esophageal disorders
  • Gastritis
  • Ulcers
  • Hypocalcemia and other disorders of mineral metabolism including vitamin D deficiency
  • Kidney insufficiency
  • Pregnancy
  • Breastfeeding
  • Children


Alendronate may interact with the following medicines:

  • Calcium supplements
  • Antacids
  • Aspirin-containing drugs
  • NSAIDs
  • Intravenous ranitidine

If you think you have used Alendronate more than the usual dosage, please seek medical help immediately.

Symptoms of overdose include the following:

  • Hypocalcemia
  • Hypophosphatemia
  • Upper gastrointestinal adverse events like upset stomach
  • Heartburn
  • Esophagitis
  • Gastritis
  • Ulcer

Available Brands:

Aldren 70, Alendra, Alendroxl, Alovell, Bondros, Fosdin, Osteomax, Reventa

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