ALENDRONATE

Alendronate, also known as alendronic acid, is used in treating osteoporosis, irregular osteogenesis and many other bone-related disorders. It is available orally and also exists as a combination drug with vitamin D.

Osteoclasts are a type of cells that impact bone reabsorption. Alendronate binds to bone hydroxyapatite and blocks osteoclasts’ activity.

Uses

Alendronate is used in treating and preventing osteoporosis in women who had menopause. It is also prescribed to increase bone mass in men suffering from osteoporosis.

Warnings

Do not give Alendronate to people with the following conditions:

Hypersensitivity
Abnormalities of the esophagus like stricture or achalasia
Unable to stand or sit upright for at least 30 minutes
Hypocalcemia

Side Effects

Alendronate may have the following side effects:

Abdominal pain
Nausea
Dyspepsia
Constipation
Diarrhea
Flatulence
Acid regurgitation
Esophageal ulcer
Vomiting
Dysphagia
Abdominal distension
Gastritis
Gastric ulcer
Melena
Musculoskeletal (bone, muscle or joint) pain
Muscle cramps
Headache
Dizziness
Taste perversion

Precautions

Precautions

Take extra caution in patients with the following medical conditions:

Heartburn
Active upper gastro intestinal problems like dysphagia
Esophageal disorders
Gastritis
Ulcers
Hypocalcemia and other disorders of mineral metabolism including vitamin D deficiency
Kidney insufficiency
Pregnancy
Breastfeeding
Children

Interactions

Alendronate may interact with the following medicines:

Calcium supplements
Antacids
Aspirin-containing drugs
NSAIDs
Intravenous ranitidine

Overdose & Brands

If you think you have used Alendronate more than the usual dosage, please seek medical help immediately.

Symptoms of overdose include the following:

Hypocalcemia
Hypophosphatemia
Upper gastrointestinal adverse events like upset stomach
Heartburn
Esophagitis
Gastritis
Ulcer

Available Brands:

Aldren 70, Alendra, Alendroxl, Alovell, Bondros, Fosdin, Osteomax, Reventa