AMMONIUM CHLORIDE

ACETYLCHOLINE

Acetylcholine is a drug that is also known as a quaternary ammonium parasympathomimetic. It is a neurotransmitter inside the body that is discharged from postganglionic parasympathetic nerves to create activities relating to the muscarine. It affects the parasympathetic sensory system, further causing vasodilation, cardiovascular depression, miosis, and lower intraocular pressure. Furthermore, it likewise has activities that compare to nicotine effects on skeletal muscle, autonomic ganglia, and adrenal medulla.

Acetylcholine is can be found in the vesicles located at the end of cholinergic (acetylcholine-producing) neurons. A nerve impulse makes it as last part of a motor neuron in the peripheral nervous system, acetylcholine is not included in the neuromuscular junction. Then it will be connected to the postsynaptic membrane of the muscle fibers. The permeability of the membrane can cause channels to be available as a change, further allowing positively-charged sodium ions to get into the muscle cells. If successive nerve impulses accumulate with high frequency, sodium channels along the end-plate membrane can reactive bringing about muscle cell contraction. This also happens in the autonomic nervous system, where an impulse is discharged from the terminal of one neuron to connect with the receptors on the postsynaptic membrane of the other cells. The bodily processes can be interrupted, including the cardiovascular system acting as a vasodilator decreasing heart rate and muscle contraction. The stomach gives a higher amplitude of digestive contractions of the gastrointestinal system in the peripheral nervous system.

This drug is used in the following conditions:

  • Miosis during surgery

Do not use Acetylcholine in people with the following conditions:

  • Hypersensitivity
  • Acute iritis
  • Acute inflammatory disease

Acetylcholine may have the following side effects:

  • Nausea
  • Vomiting
  • Abdominal pain
  • Salivation
  • Lachrymation
  • Rhinorrhoea
  • Eructation
  • Diarrhea
  • Urinary frequency
  • Headache
  • Peripheral vasodilation
  • Corneal edema
  • Clouding

Take extra caution in patients with the following medical conditions:

  • Patient with anterior or posterior synechiae
  • Asthma
  • Obstructive airway disease
  • Heart and blood vessel disorders
  • Bradycardia
  • Heart block
  • Recent heart attack
  • Hypotension
  • Vagotonia
  • Epilepsy
  • Parkinsonism
  • Hyperthyroidism
  • Peptic ulcer

Interactions

Acetylcholine may interact with the following medicines:

  • Neostigmine
  • Metoprolol
  • Ophth NSAIDs
  • If you think you have used Acetylcholine more than the usual dosage, please seek medical help immediately.Symptoms of overdose include the following:
    • Bradycardia
    • Hypotension
    • Flushing
    • Breathing difficulty
    • Sweating

    Available Brands:

    Miochol

    If you think you have used Acetylcholine more than the usual dosage, please seek medical help immediately.

    Symptoms of overdose include the following:

    • Bradycardia
    • Hypotension
    • Flushing
    • Breathing difficulty
    • Sweating

    Available Brands:

    Miochol

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