Acetaminophen is used to relieve pain and reduce fever. Dextromethorphan (DM) is a cough suppressant that reduces the urge to cough by affecting certain part of the brain. Guaifenesin is an expectorant that helps loosen congestion in the chest and throat. It works by making it easier to cough out through your mouth. Phenylepherine is a decongestant that relieves nasal congestion by shrinking the blood vessels in the nasal passages.

This combination medication is used to treat symptoms caused by the common cold, flu, allergies, or other breathing illnesses (such as sinusitis, bronchitis), temporarily. This medication may also be used in other conditions to be determined by your doctor.

Do not use this drug:

  • If you are allergic to Acetaminophen, Dextromethorphan, Guaifenesin and Phenylephrine
  • If you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems
  • If you are unable to urinate or are having an asthma attack
  • If you are taking Droxidopa, Sodium Oxybate (GHB), or you have taken Furazolidone or a Monoamine Oxidase Inhibitor (MAOI) (eg, Phenelzine) within the last 14 days

Common side effects of this drug may include:

  • Constipation
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Dry Mouth, Nose, or Throat
  • Excitability
  • Headache
  • Nervousness
  • Trouble Sleeping
  • Upset Stomach


Notify your doctor promptly if any of these symptoms persist or worsen.


Your doctor may have prescribed this medication because he or she judged that the benefit to you is greater than the risk of side effects.

Serious side effects may include:

  • Severe Allergic Reactions
  • Confusion
  • Fast or Irregular Heartbeat
  • Fever, Chills, or Persistent Sore Throat
  • Hallucinations
  • Redness
  • Seizures
  • Severe Dizziness, Drowsiness, Lightheadedness or Headache
  • Severe or Persistent Nervousness or Trouble Sleeping
  • Shortness of Breath
  • Symptoms of Liver Problems (eg, Dark Urine, Loss of Appetite, Pale Stools, Stomach Pain, Yellowing of the Skin or Eyes)
  • Tremor
  • Trouble Urinating or Inability to Urinate
  • Vision Changes

Seek immediate medical attention if you experience any of these serious side effects.


Before taking this drug, tell your doctor or pharmacist:

  • If you are allergic to any content of this drug or if you have other allergies.
  • If you are pregnant, planning to become pregnant, or are breast-feeding
  • If you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • If you have a fast, slow, or irregular heartbeat
  • Your medical history, especially of:
    • Adrenal Gland Problems (eg, Adrenal Gland Tumor)
    • Heart Problems (eg, Fast, Slow, or Irregular Heartbeat)
    • High Blood Pressure
    • Diabetes
    • Blood Vessel Problems
    • Stroke
    • Glaucoma or Increased Pressure in the Eye
    • Thyroid Problems
    • Asthma
    • Chronic Cough, Lung or Breathing Problems (eg, Chronic Bronchitis, Emphysema, Sleep Apnea)
    • Chronic Obstructive Pulmonary Disease (COPD) or if your Cough Occurs with Large Amounts of Mucus
    • Stomach or Bowel Ulcers
    • A Blockage of your Stomach, Bladder, or Bowel
    • Kidney Problems
    • Liver Problems
    • An Enlarged Prostate or other Prostate Problems
    • Trouble Urinating
  • If you have a history of alcohol abuse or if you are smoking



Drug interactions may either lessen the effectiveness of this drug or heighten the risk for severe side effects. It’s important to inform your doctor all the medication including prescription and non-prescription and herbal medicines you are taking or going to take.

Possible interactions with this drug are:

  • Anticoagulants (eg, Warfarin)
  • Digoxin
  • Droxidopa
  • Beta-Blockers (eg, Propranolol)
  • Catechol-O-Methyltransferase (COMT) Inhibitors (eg, Tolcapone)
  • Furazolidone
  • Indomethacin
  • Isoniazid
  • Maois (eg, Phenelzine)
  • Sodium Oxybate (GHB)
  • Tricyclic Antidepressants (eg, Amitriptyline)
  • Bromocriptine or Hydantoins (eg, Phenytoin)
  • Guanadrel
  • Guanethidine
  • Mecamylamine
  • Methyldopa
  • Reserpine

Call emergency hotline if someone has overdosed and has serious symptoms such as passing out or trouble breathing.

Symptoms of overdose may include:

  • Blurred Vision
  • Confusion
  • Dark Urine
  • Hallucinations
  • Nausea
  • Vomiting
  • Stomach Pain
  • Seizures
  • Severe Dizziness, Lightheadedness, or Headache
  • Severe Drowsiness
  • Unusually Fast, Slow, or Irregular Heartbeat

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