Acetaminophen is used to relieve pain and reduce fever. Chlorpheniramine (CPM) is an antihistamine that helps relieve symptoms such as watery eyes; itchy eyes, nose, throat; runny nose; and sneezing. Dextromethorphan (DM) is a cough suppressant that reduces the urge to cough by affecting certain part of the brain. Pseudoephedrine is a decongestant that relieves nasal congestion by shrinking the blood vessels in the nasal passages.

This combination medication is used to treat symptoms such as pain, sinus congestion, runny nose, sneezing, and cough due to colds, upper respiratory infections, and allergies. This medication may also be used in other conditions to be determined by your doctor.

Do not use this drug:

  • If you are allergic to any ingredient to any ingredient of this drug
  • If you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems
  • If you are unable to urinate or are having an asthma attack
  • If you have taken Sodium Oxybate (GHB) or you have taken Furazolidone or a Monoamine Oxidase (MAO) inhibitor (eg, Phenelzine) within the last 14 days

Common side effects may include:

  • drowsiness
  • dry eyes, mouth
  • loss of appetite
  • stomach upset

Notify your doctor promptly if any of these symptoms persist or worsen.

Your doctor may have prescribed this medication because he or she judged that the benefit to you is greater than the risk of side effects.

Serious side effects may include:

  • Allergic Reactions Like Skin Rash, Itching or Hives, Swelling of the Face, Lips, or Tongue
  • Chest Pain or Tightness
  • Dizziness, Nervousness, or Sleeplessness
  • Fast, Irregular Heartbeat
  • Trouble Passing Urine or Change in the Amount Of Urine
  • Unusual Bleeding or Bruising
  • Unusually Weak or Tired
  • Yellowing of the Eyes or Skin


Before taking this drug, tell your doctor or pharmacist:

  • If you are allergic to any of its content or if you have other allergies.
  • if you are pregnant, plan to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have a fast, slow, or irregular heartbeat
  • Your medical history, especially of:
    • Adrenal Gland Problems (eg, Adrenal Gland Tumor)
    • Heart Problems
    • High Blood Pressure
    • Diabetes
    • Heart Blood Vessel Problems
    • Stroke
    • Glaucoma
    • A Blockage of your Stomach
    • Bladder
    • Intestines
    • Ulcers
    • Trouble Urinating
    • An Enlarged Prostate or other Prostate Problems
    • Seizures
    • Overactive Thyroid
    • Liver Problems
    • Asthma
    • Chronic Cough, Lung Problems (eg, Chronic Bronchitis, Emphysema), or Chronic Obstructive Pulmonary Disease (Copd), or if your Cough Occurs with Large Amounts of Mucus
    • Use and Abuse of Alcohol



Drug interactions may either lessen the effectiveness of this drug or heighten the risk for severe side effects. It’s important to inform your doctor all the medication including prescription and non-prescription and herbal medicines you are taking or going to take.

Possible interactions with this drug are:

  • Cold Medicine
  • Alcohol
  • Mao Inhibitor (Furazolidone (Furoxone)
  • Isocarboxazid (Marplan)
  • Phenelzine (Nardil)
  • Rasagiline (Azilect)
  • Selegiline (Eldepryl, Emsam, Zelapar)
  • Tranylcypromine (Parnate)

Call emergency hotline if someone has overdosed and has serious symptoms such as passing out or trouble breathing.

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