Acetaminophen is used to relieve pain and reduce fever. Caffeine is a stimulant and works by relaxing the muscle contractions in blood vessels to improve blood flow. Phenyltoloxamine is an antihistamine and works by reducing the symptoms brought by the natural substance histamine to our body such as watery eyes, runny nose and sneezing. Salicylamide have analgesic and antipyretic properties and works like an Aspirin.

This combination medication is used to treat minor aches and pains such as headaches, muscle or joint soreness, minor toothache and menstrual cramps. This medication may also be used to relieved symptoms caused by colds, arthritis, muscle spasm, and sinusitis.

Do not use this drug:

  • If you are allergic to any ingredient of this drug or if you have other allergies
  • If you have had a severe allergic reaction to aspirin or other salicylates
  • If you have kidney or liver problems
  • To children or teenager with a viral infection (eg, Chickenpox, Flu, Cold)
  • If you are taking Sodium Oxybate (GHB) or an Anticoagulant (eg, Warfarin)

Common side effects may include:

  • Dizziness
  • Drowsiness
  • Dry Mouth, Nose, or Throat
  • Heartburn
  • Nausea
  • Thickening of Mucus in the Nose and Throat
  • Upset Stomach

Serious side effects may include:

  • Severe Allergic Reactions (Rash; Hives; Itching; Difficulty Breathing; Tightness in the Chest; Swelling of the Mouth, Face, Lips, or Tongue)
  • Bloody or Black Stools
  • Blurred Vision or Other Vision Changes
  • Dark Urine
  • Decrease in the Amount of Urine Produced
  • Difficulty Urinating
  • Fainting
  • Fast or Irregular Heartbeat
  • Hearing Loss
  • Involuntary Trembling
  • Loss of Coordination
  • Pale Stools
  • Ringing in the Ears
  • Seizures
  • Severe or Persistent Dizziness
  • Severe Stomach Pain
  • Trouble Sleeping
  • Unusual Bruising or Bleeding
  • Unusual Tiredness
  • Vomiting
  • Yellowing of the Skin or Eyes


Before taking this drug, tell your doctor or pharmacist:

  • If you have allergies to any content of this drug or if you have other allergies.
  • If you are pregnant, planning to become pregnant, or are breast-feeding
  • If you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • If you have certain medical condition such as:
    • Viral Infection (eg, Chickenpox, Flu)
    • Kawasaki Syndrome
    • Ulcers
    • A Blockage of your Stomach, Bowel, or Bladder
    • Blood or Bleeding Problems
    • Blood Clotting Problems
    • Heart Problems
    • Blood Vessel Problems
    • High Blood Pressure
  • If you have a medical history, especially of:
    • Lung or Breathing Problems (eg, Asthma, Emphysema, Chronic Obstructive Pulmonary Disease [COPD])
    • Increased Pressure in the Eye
    • Glaucoma
    • Difficulty Urinating
    • Prostate Problems (eg, Enlarged Prostate)
    • Anxiety
    • Trouble Sleeping
    • High Blood Sugar
  • if you have a history of alcohol abuse or dependence, or if you take Monoamine Oxidase inhibitor (MAOI) (eg, Phenelzine)



Drug interactions may either lessen the effectiveness of this drug or heighten the risk for severe side effects. It’s important to inform your doctor all the medication including prescription and non-prescription and herbal medicines you are taking or going to take.

Possible interactions with this drug are:

  • Sodium oxybate (GHB)
  • Anticoagulants (eg, Warfarin)
  • Aspirin
  • Isoniazid
  • MAOIs (eg, Phenelzine)
  • Quinolones (eg, Ciprofloxacin)
  • Theophylline
  • Barbiturates (Eg, Phenobarbital)

Call emergency hotline if someone has overdosed and has serious symptoms such as passing out or trouble breathing.

Symptoms of overdose may include:

  • Abnormal Thoughts or Behaviour
  • Confusion
  • Dark Urine
  • Excessive Sweating
  • Fast or Deep Breathing
  • Fast or Irregular Heartbeat
  • General Discomfort
  • Hearing Loss
  • High Fever
  • Involuntary Trembling
  • Ringing in the Ears
  • Seizures
  • Severe or Persistent Stomach Pain
  • Trouble Sleeping
  • Vomiting
  • Yellowing of the Eyes or Skin

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