Acetaminophen is used to relieve pain and reduce fever. Caffeine is a stimulant and works by relaxing the muscle contractions in blood vessels to improve blood flow. Isometheptene is also causes narrowing of blood vessels and is used to treat migraines and tension headaches.

This combination medication is used to treat migraine headaches or severe tension headaches.

Do not use this drug:

  • If you have taken a MAO inhibitor in the past 14 days.
  • If you have certain conditions such as liver disease, severe kidney disease, heart disease, high blood pressure, or glaucoma.

Common side effects may include:

  • Dizziness
  • Mild Skin Rash
  • Sleep Problems (Insomnia)
  • Feeling Nervous, Irritable, or Jittery

Notify your doctor promptly if any of these symptoms persist or worsen.


Your doctor may have prescribed this medication because he or she judged that the benefit to you is greater than the risk of side effects.

Serious side effect may include:

  • Low Fever With Nausea
  • Stomach Pain
  • Loss of Appetite
  • Dark Urine
  • Clay-Colored Stools
  • Jaundice (Yellowing of the Skin or Eyes)

Seek immediate medical attention if you experience any of these serious side effects.


Before taking this product, tell your doctor or pharmacist:

  • If you are allergic to any of its ingredients or if you have any other allergies.
  • If you are to undergo any surgery.
  • If you are pregnant or breastfeeding.



Drug interactions may either lessen the effectiveness of this drug or heighten the risk for severe side effects. It’s important to inform your doctor all the medication including prescription and non-prescription and herbal medicines you are taking or going to take.

Possible interactions with this drug are:

  • Alcohol
  • Coffee, Tea Cola, Diet Pills, Energy Drinks or other Sources of Caffeine
  • Other Cold, Allergy, Pain, or Sleep Medication
  • Isometheptene

Call emergency hotline if someone has overdosed and has serious symptoms such as passing out or trouble breathing.

  • Loss of Appetite
  • Nausea
  • Vomiting
  • Stomach Pain
  • Sweating
  • Confusion or Weakness
  • Pain in your Upper Stomach
  • Dark Urine
  • Yellowing of your Skin or the Whites of your Eyes

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