ACEMETACIN

 

Description: Acemetacin belongs to a class of painkillers called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the effect of chemicals called cyclo-oxygenase (COX) enzymes. These enzymes help to make other chemicals in the body, called prostaglandins. Some prostaglandins are produced at sites of injury or damage, and cause pain and inflammation. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which eases pain and inflammation.

Acemetacin is used to ease pain and reduce inflammation in rheumatic conditions such as osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It is also prescribed to ease pain after surgical operations.

Acemetacin should not be given to pregnant women (third trimester) and patients with:

  • Hypersensitivity to acemetacin or indometacin and other NSAIDs
  • Active or history of peptic ulcer/hemorrhage
  • History of gastrointestinal bleeding or perforation related to previous NSAID therapy
  • Blood formation disorder of unclear etiology
  • Nasal polyps (associated w/ angioneurotic edema)
  • Severe heart failure, kidney and liver impairment

This drug may cause dizziness, drowsiness, fatigue, and visual disturbances; if affected, do not drive or operate machinery.

Common side effects include gastrointestinal problems typical of NSAIDs, such as nausea, diarrhea, stomach pain, and peptic ulcer; central nervous effects like headache and dizziness; and skin reactions.

Important: if you experience any of the following less common but more serious symptoms, stop taking acemetacin and contact your doctor for advice straightaway:

  • If you have any breathing difficulties such as wheeze or breathlessness.
  • If you have any signs of an allergic reaction such as swelling around your mouth or face, or a severe itchy skin rash.
  • If you pass blood or black stools, vomit blood, or have severe abdominal pains.

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist for further advice.

Precautions

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking acemetacin, it is important that your doctor knows:

  • If you have asthma or any other allergic disorder.
  • If you have ever had a stomach or duodenal ulcer, or if you have an inflammatory bowel disorder such as Crohn’s disease or ulcerative colitis.
  • If you are pregnant, trying for a baby, or breast-feeding.
  • If you are under 18 or over 65 years of age.
  • If you have liver or kidney problems.
  • If you have a heart condition, or a problem with your blood vessels or circulation.
  • If you have high blood pressure.
  • If you have ever had blood clotting problems.
  • If you have a connective tissue disorder, such as systemic lupus erythematosus (an inflammatory condition also called lupus, or SLE).
  • If you have a rare blood disorder known as porphyria.
  • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • If you have ever had an allergic reaction to any other NSAID (such as aspirin, naproxen, diclofenac, and indometacin) or to any other medicine.

 

Interactions

  • May increase risk of adverse reaction with other NSAIDs
  • Increased gastrointestinal ulceration/bleeding w/ corticosteroids, anti-platelet agents, and SSRIs (anti-depressants)
  • Reduced resorption rate with antacids
  • Reduced elimination with probenecid and sulfinpyrazone
  • May reduce the effect of diuretics and antihypertensive agents
  • May reduce elimination of phenytoin, lithium, methotrexate
  • Increased risk of kidney toxicity with ciclosporin and diuretics

Overdose symptoms include bleeding, vomiting or couging up of blood, bloody urine (with renal colic), bruising, heavy menstrual bleeding, fast heart beat, low blood pressure, nausea, vomiting, diarrhea, and abdominal pain. If overdose is suspected, bring the victim to the hospital immediately.

Available brands:

  • Rantudil (Bayer)

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