Description: Acemetacin belongs to a class of painkillers called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the effect of chemicals called cyclo-oxygenase (COX) enzymes. These enzymes help to make other chemicals in the body, called prostaglandins. Some prostaglandins are produced at sites of injury or damage, and cause pain and inflammation. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which eases pain and inflammation.