ABCIXIMAB - Watsons Health

ABCIXIMAB

COMMON BRAND NAME: Reopro

GENERIC NAME: ABCIXIMAB

 

Description: Abciximab acts by binding to certain protein receptors (Iib or IIIa) on platelet surface thus inhibiting fibrinogen binding preventing platelet aggregation.

  • Type of “blood thinner” used to prevent blood clots during certain procedures used to open up the blood vessels in the heart (e.g., balloon angioplasty, coronary stent placement, percutaneous coronary intervention-PCI). It is usually used with heparin and aspirin.
    • Prevents platelets in the blood from sticking to each other and forming clots.
  • Follow all instructions for proper mixing and dilution with the correct IV fluids. If you have questions about using this medication properly, consult your pharmacist.
  • Do not shake the medication. Before using this product, check it visually for particles or discoloration.
    • If either is present, do not use the liquid.
  • Given by injection into a vein by a health care professional.
    • usually 10 to 60 minutes before procedure, then given slowly into a vein for up to 12 hours or as directed by a doctor.
    • If you are having uncontrolled chest pain and your procedure cannot be done immediately, this medication may be started up to 24 hours before your procedure and continued until 1 hour after the procedure is finished.
    • The dosage is based on your weight, medical condition, and response to treatment.After your procedure, you will need to lie very still with your head up slightly.
  • The tube for your procedure is usually placed near the groin. Keep the leg (or other limb nearest the tube) straight to prevent bleeding from the tube area. Pressure will be applied to the area.
  • You will not be allowed out of bed for several hours after the procedure.

Commonly reported

  • Major hemorrhage or hemorrhage, chest pain, hypotension, nausea, back pain.

Minor side effects (if these symptoms persist or worsen, inform your doctor)

  • Back pain, acid or sour stomach, belching, burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings, changes in vision, delusions, dementia, fear, heartburn, indigestion or stomach discomfort, upset or pain, mood or mental changes, nausea, nervousness, vomiting.

Serious side effects (inform your doctor immediately)

  • Bleeding, blurred vision; confusion; dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly; sweating; unusual tiredness or weakness, black, tarry stools, bleeding gums,blood in urine or stools, pinpoint red spots on skin, unusual bleeding or bruising.
  • May rarely cause: Chest pain or discomfort, chills, cough, eye pain, fever, general feeling of illness, headache, pale skin, rapid weight gain, shortness of breath, slow or irregular heartbeat, sneezing, sore throat, swelling of hands, ankles, feet, or lower legs, tightness in chest, tingling of hands or feet, troubled breathing, unusual tiredness, wheezing.

Precautions

  • Inform your doctor if you have/experienced:
    • Allergy to medicne or any other allergies i.e. to mouse proteins.
    • Current bleeding, bleeding from the gut or bladder in the last 6 weeks (e.g., bleeding peptic ulcer), stroke in the last 2 years, history of stroke with continuing problems (e.g., slurred speech, weak muscles, vision problems), major surgery/injury/other bleeding in the last 6 weeks, brain tumor, blood vessel problem in the brain (e.g., aneurysm, AV malformation), very high uncontrolled blood pressure, inflammation of the blood vessels (vasculitis).
  • Tell your doctor your medical history, especially of:
    • Use of this drug in the last 30 days
    • Stomach/intestinal problems (e.g., peptic ulcer, inflammatory bowel disease)
    • Low blood platelets (thrombocytopenia)
    • Liver disease
  • Consult doctor if pregnant or breastfeeding.

 

Drug Interactions

Taking multiple drugs may affect how medications work and/or cause unwanted side effects. List down all the medications you are taking and inform your physician and pharmacist. Do not take, discontinue, or alter any dose of medications without prior approval of your physician.

  • This drug should not be used with the following medication because a very serious interaction may occur: dextran.
    • If you are currently using the medication listed above, tell your doctor or pharmacist before starting abciximab.
  • Tell your doctor about your medications especially about:
    • Other “blood thinners” (e.g., warfarin) used in the last 7 days, NSAIDs (e.g., ibuprofen, naproxen), anti-platelet drugs (e.g., dipyridamole, ticlopidine), tipranavir.

If overdose is suspected, contact a local poison control center or emergency room immediately.

Laboratory and/or medical tests (e.g., bleeding times, platelet count) should be performed periodically to monitor your progress or check for side effects

Missed Dose: If your dose is stopped or interrupted, contact the doctor immediately to establish a new dosing schedule/rate.

Storage

  • Refrigerate between 2-8 degrees C (36-46 degrees F)
  • Do not freeze
  • Discard any unused liquid
  • Keep all medicines away from children and pets
  • Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
  • Properly discard this product when it is expired or no longer needed

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